RecruitingPhase 2NCT05434130

Modulating Exercise Dosage to Improve Concussion Recovery

Modulating Exercise Dosage to Improve Concussion Recovery: a Randomized Clinical Trial

Sponsor

University of Colorado, Denver

Enrollment

216 participants

Start Date

Aug 5, 2022

Study Type

INTERVENTIONAL

Conditions

Treatment Depression, Anxiety Aerobic Exercise Inflammation Concussion, Brain

Summary

Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.

Eligibility

Min Age: 13 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether different levels (doses) of aerobic exercise can help teenagers recover faster from a concussion. Researchers want to find the right amount of exercise — not too little and not too much — to speed up recovery without making symptoms worse. **You may be eligible if:** - You are between 13 and 18 years old - You have been diagnosed with a concussion by a sports medicine doctor - You still have concussion symptoms (symptom score above 10) **You may NOT be eligible if:** - You have a pre-existing neurological condition - There is a medical reason why you should not exercise - You have had another concussion within the past 6 months (not counting your current one) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALHigh Dose Exercise

The investigators will initially test and randomize adolescents ages 13-18 years old ≤14 days post-concussion to high dose aerobic exercise (\>150 min/week, individualized intensity level) or standard-of-care (symptom limited, self-guided physical activity), and re-test upon symptom resolution and 8-weeks post symptom resolution