Vascular Malformation Clinical Trials

2 recruiting

Frequently Asked Questions

Common questions about Vascular Malformation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Phase 2

A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations

PI3K Gene MutationVascular AnomaliesArteriovenous Malformations+11 more
Murdoch Childrens Research Institute50 enrolled2 locationsNCT05983159
Recruiting
Phase 2

A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation

PIK3CA MutationVascular MalformationsPIK3CA-Related Overgrowth Spectrum (PROS)+4 more
Relay Therapeutics, Inc.277 enrolled25 locationsNCT06789913
Recruiting
Phase 1Phase 2

Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of CYH33 in Patients With PIK3CA-related Overgrowth Spectrum (PROS) and PIK3CA-related Vascular Malformations (PRVM)

PIK3CA-Related Overgrowth Spectrum (PROS)PIK3CA-related Vascular Malformations (PRVM)
Haihe Biopharma Co., Ltd.141 enrolled4 locationsNCT06975618
Recruiting
Phase 2

An Open-Label, Single-Arm Exploratory Clinical Study of Everolimus for the Treatment of Vascular Malformations

Vascular Malformations
Xuanwu Hospital, Beijing10 enrolled1 locationNCT07037238
Recruiting

Patient Reported Outcomes for Vascular Malformations EmbolizatioN (PROVEN)

Vascular MalformationsVM - Vascular Malformation
Johns Hopkins University200 enrolled1 locationNCT04104464
Recruiting

Beacon Tip Sizing Catheter and Slip-Cath Beacon Tip Catheter Study

StrokeStenosisTIA+3 more
Cook Research Incorporated588 enrolled1 locationNCT06986954
Recruiting
Phase 2

A Study of Enalapril in Treatment of Venous Malformations

PainQuality of LifeVenous Malformation+1 more
Oslo University Hospital12 enrolled1 locationNCT06788314
Recruiting

Identification of Biomarkers for Patients with Vascular Anomalies

Vascular AnomalyKlippel Trenaunay SyndromeKaposiform Hemangioendothelioma+4 more
Children's Hospital Medical Center, Cincinnati1,000 enrolled2 locationsNCT03001180
Recruiting

Treatment of Low-flow Venous Malformations With Electrosclerotherapy. Prospective Observational Study

Vascular Malformations
Istituto Ortopedico Rizzoli65 enrolled1 locationNCT06189092
Recruiting
Phase 3

Efficacy and Safety of Sirolimus in Vascular Anomalies That Are Refractory to Standard Care

Vascular Malformations
Cliniques universitaires Saint-Luc- Université Catholique de Louvain250 enrolled3 locationsNCT02638389
Recruiting

Use of the GPX Embolic Device in Patients Requiring Embolization

VaricoceleRenal or hepatic tumor requiring pre-operative embolizationNeed for coil-assisted branch artery embolization pre-endovascular aneurysm repair (EVAR)+5 more
Fluidx Medical Technology, LLC20 enrolled2 locationsACTRN12620001194954
Recruiting
Phase 1

5 year study of 6 children each year with vascular anomalies who have severe complications failing to respond to the usual treatments will be offered a new use of an old medication- sirolimus

PIKC3A related overgrowth syndrome (PROS)Vascular tumours (tufted angiomas and kaposiform haemangioendotheliomas)Complex lymphatic malformations+2 more
Sydney Children's Hospital, Randwick30 enrolled1 locationACTRN12616000943448