Defactinib Clinical Trials

11 recruitingDrug
Phase 29Phase 13Phase 31

Showing 111 of 11 trials

Recruiting
Phase 2

A Study of Avutometinib (VS-6766) and Defactinib in People With Mesonephric Gynecologic Cancer

Mesonephric Gynecologic Cancer
Memorial Sloan Kettering Cancer Center40 enrolled7 locationsNCT05787561
Recruiting
Phase 2

A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer

Memorial Sloan Kettering Cancer Center20 enrolled8 locationsNCT06394804
Recruiting
Phase 2

Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma

Pancreatic CancerPancreas CancerPancreatic Adenocarcinoma+1 more
Washington University School of Medicine36 enrolled1 locationNCT07126158
Recruiting
Phase 3

A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Low Grade Serous Ovarian Cancer
Verastem, Inc.270 enrolled106 locationsNCT06072781
Recruiting
Phase 2

Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer

Stage III Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8Advanced Lung Adenocarcinoma+1 more
Emory University50 enrolled3 locationsNCT06495125
Recruiting
Phase 2

Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer

Advanced Colorectal Cancer
M.D. Anderson Cancer Center33 enrolled1 locationNCT06369259
Recruiting
Phase 2

A Study of Avutometinib and Defactinib in People With Thyroid Cancer

Thyroid Cancer
Memorial Sloan Kettering Cancer Center30 enrolled7 locationsNCT06007924
Recruiting
Phase 1

Combined Evaluation of Epigenetic and Sensitising Therapy in AML and MDS

Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myelomonocytic Leukemia
Clinical Hub for Interventional Research (CHOIR)12 enrolled5 locationsNCT05636514
Recruiting
Phase 1Phase 2

5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours

Glioblastoma Multiforme (GBM)Malignant Primary GliomasGlioblastoma Multiform (Grade IV Astrocytoma)+1 more
Institute of Cancer Research, United Kingdom182 enrolled3 locationsNCT06630260
Recruiting
Phase 1Phase 2

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

Cutaneous MelanomaBrain Metastases
University of Utah33 enrolled2 locationsNCT06194929
Recruiting
Phase 2

Avutometinib and Defactinib in Diffuse Gastric Cancer

Gastric CancerStomach Cancer
Ryan H. Moy, MD, PhD27 enrolled1 locationNCT06487221