Phase 1 Clinical Trials for Healthy Volunteers
First-in-human drug safety and dosing studies that compensate healthy adults.
There are 449 actively recruiting Phase 1 clinical trials enrolling healthy volunteers. Phase 1 studies test investigational drugs for safety and dosing in small groups under close medical supervision. Updated daily from ClinicalTrials.gov.
What is a Phase 1 trial?
Phase 1 is the first stage of human testing. A small group of healthy volunteers receives the investigational drug to evaluate safety, tolerability, and pharmacokinetics. Participants are monitored closely — often as inpatients at a clinical pharmacology unit — and compensated for their time. These studies are reviewed and approved by an ethics committee before enrollment begins.
Showing 241–260 of 449 Phase 1 studies
A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults
A Study of Calderasib (MK-1084) in Participants With Hepatic Impairment and Healthy Volunteers (MK-1084-017)
A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity
A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants
A Phase Ia Clinical Trial of HW241045
A Study to Investigate the Concentrations of Zibotentan and Dapagliflozin in Blood When Given With and Without Food
A Study of Remternetug (LY3372993) in Healthy Chinese Participants
A Study to Assess How the Body Absorbs ABBV-8736 Subcutaneous Injections Relative to Intravenous Injections in Adult Healthy Volunteers
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
Study of the Safety, Tolerability, Pharmacokinetics of VV261 Tablets in Chinese Healthy Volunteers
A Study of LY4515100 in Healthy Participants
A Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY4066708 in Healthy Participants
A Study of V118E in Healthy Participants (V118E-003)
First-in-human Study of Orally Administered KT-579 in Healthy Adult Participants
A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
Pharmacokinetic Comparison of Vonafexor Acid and Its Lysine Salt and Evaluation of Potential Drug-Drug Interactions
A Study to Learn How the Study Medicine Called PF-08653944 is Taken up Into the Blood in Adults With Overweight or Obesity.
A Single- and Multiple-Ascending Dose Study of SRK-439 in Healthy Adults
A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years
A Study to Compare Blood Levels of Different Dosage Formulations of the Study Medicine That Is a CGRP Receptor Antagonist in Healthy Adults
Phase 1 FAQ
How much do Phase 1 trials pay?
Compensation varies by study duration and intensity. Inpatient Phase 1 studies (multi-day residential stays) typically pay $1,000–$5,000+. Outpatient studies with follow-up visits may pay $200–$1,500. Specific amounts are disclosed in the informed consent document.
Are Phase 1 trials safe?
Phase 1 trials carry some risk as participants receive an investigational drug. All studies are reviewed and approved by an ethics committee (IRB/HREC) before enrollment begins. Participants are monitored continuously and can withdraw at any time.
What happens during a Phase 1 study?
Typically you attend a screening visit, then either stay at the clinical unit (inpatient) or visit regularly (outpatient). Blood draws, vital signs, and other assessments are conducted at scheduled intervals. The study team monitors you throughout and provides meals and accommodation for inpatient stays.