Phase 1 Clinical Trials for Healthy Volunteers
First-in-human drug safety and dosing studies that compensate healthy adults.
There are 449 actively recruiting Phase 1 clinical trials enrolling healthy volunteers. Phase 1 studies test investigational drugs for safety and dosing in small groups under close medical supervision. Updated daily from ClinicalTrials.gov.
What is a Phase 1 trial?
Phase 1 is the first stage of human testing. A small group of healthy volunteers receives the investigational drug to evaluate safety, tolerability, and pharmacokinetics. Participants are monitored closely — often as inpatients at a clinical pharmacology unit — and compensated for their time. These studies are reviewed and approved by an ethics committee before enrollment begins.
Showing 361–380 of 449 Phase 1 studies
A Study of EDG-15400 in Healthy Adults
A Study of IBI3032 in Healthy Participants
Evaluation of the Pharmacokinetics of "PBK_M2301" in Healthy Adults
A Study to Evaluate Single-dose of HB0056 in Healthy Adult Participants
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
Phase 1 Study of SL-325 in Healthy Volunteers
PK and Safety Comparison of DWJ1511 and DWC202501 in Healthy Volunteers
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of ABBV-277 in Healthy Adult Participants
Food Effect on PK of DW-1021 (Pelubiprofen 45 mg / Tramadol 45.9 mg) in Healthy Adults
Comparison of DW-1021 and Separate Doses of Pelubi CR and Zytram CR Under Fasting Conditions
Study of S-892216 Long-acting Injectable (LAI) in Healthy Adult Participants
Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population
Study of HX15001 in Adult Healthy Volunteers.
Assess the Safety, Tolerability, and Pharmacokinetics of HL-1186 in Healthy Participants
A Study to Evaluate the Food Effect on the Pharmacokinetics of DA-5223 in Healthy Adult Subjects
A Study of SPY002-091 in Healthy Volunteers
Comparative Acute Effects of R-MDMA and S-MDMA in Healthy Participants
A First-in-Human Study of PRD001
Psilocybin Brain Stimulation and Imaging Pilot Study
Pharmacokinetics and Safety of M107 Orally Disintegrating Tablet in Healthy Adults
Phase 1 FAQ
How much do Phase 1 trials pay?
Compensation varies by study duration and intensity. Inpatient Phase 1 studies (multi-day residential stays) typically pay $1,000–$5,000+. Outpatient studies with follow-up visits may pay $200–$1,500. Specific amounts are disclosed in the informed consent document.
Are Phase 1 trials safe?
Phase 1 trials carry some risk as participants receive an investigational drug. All studies are reviewed and approved by an ethics committee (IRB/HREC) before enrollment begins. Participants are monitored continuously and can withdraw at any time.
What happens during a Phase 1 study?
Typically you attend a screening visit, then either stay at the clinical unit (inpatient) or visit regularly (outpatient). Blood draws, vital signs, and other assessments are conducted at scheduled intervals. The study team monitors you throughout and provides meals and accommodation for inpatient stays.