Phase 1 Clinical Trials for Healthy Volunteers
First-in-human drug safety and dosing studies that compensate healthy adults.
There are 449 actively recruiting Phase 1 clinical trials enrolling healthy volunteers. Phase 1 studies test investigational drugs for safety and dosing in small groups under close medical supervision. Updated daily from ClinicalTrials.gov.
What is a Phase 1 trial?
Phase 1 is the first stage of human testing. A small group of healthy volunteers receives the investigational drug to evaluate safety, tolerability, and pharmacokinetics. Participants are monitored closely — often as inpatients at a clinical pharmacology unit — and compensated for their time. These studies are reviewed and approved by an ethics committee before enrollment begins.
Showing 381–400 of 449 Phase 1 studies
A Study to Assess the Safety and Effects of the Investigational Drug BW-40202 in Healthy Volunteers
A Study to Assess How the Drug Moves Through the Body, Adverse Events, and Tolerability of Oral ABBV-722 Capsules of Single and Multiple Ascending Doses in Adult Participants and Single Doses in Adult Asian Participants
HS-10542 Study in Healthy Participants
Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
A Phase I Clinical Study of a Single Dose of KLA480
A Study of FB1003 in Healthy and Osteoarthritis Pain Subjects
Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Study of CMP-CPS-001 in Healthy Volunteers
To Evaluate the Effect of Food on the Pharmacokinetics of Y-4 Tablets in Healthy Subjects
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ABSK061 Mini-tablets in Healthy Adult Participants
Identification of New Tools for Predicting Natural Metabolic Performance of the Liver
To Compare the Pharmacokinetics and Safety of PBP1502 and Humira in Healthy Subjects
Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness
A Study to Evaluate Single-dose of HB0043 in Healthy Adult Participants
A Clinical Study of AK0610
Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects
A Study of HDM1002 in Subjects With And Without Varying Degrees Of Hepatic Impairement
MAD Study of IA-14069
Validation Study of an Assistive Pulse Data Collection Device
taVNS Effects on Fear Ratings in Naturalistic Context
Phase 1 FAQ
How much do Phase 1 trials pay?
Compensation varies by study duration and intensity. Inpatient Phase 1 studies (multi-day residential stays) typically pay $1,000–$5,000+. Outpatient studies with follow-up visits may pay $200–$1,500. Specific amounts are disclosed in the informed consent document.
Are Phase 1 trials safe?
Phase 1 trials carry some risk as participants receive an investigational drug. All studies are reviewed and approved by an ethics committee (IRB/HREC) before enrollment begins. Participants are monitored continuously and can withdraw at any time.
What happens during a Phase 1 study?
Typically you attend a screening visit, then either stay at the clinical unit (inpatient) or visit regularly (outpatient). Blood draws, vital signs, and other assessments are conducted at scheduled intervals. The study team monitors you throughout and provides meals and accommodation for inpatient stays.