Mannitol and nasal mucociliary clearance
A randomised, double-blind, placebo controlled trial of the effect versus placebo of twice daily doses of mannitol (80mg) for one week on nasal mucociliary clearance in healthy adults and adults with allergic rhinitis or chronic sinusitis.
Woolcock Institute of Medical Research
36 participants
Jun 26, 2005
Interventional
Conditions
Eligibility
Plain Language Summary
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This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
A double-blind cross-over placebo controlled system will be used. Computer generated randomisation will be conducted internally by a non-study related third party. Patients will be randomly assigned to receive either mannitol first and then placebo, or placebo first and then mannitol. There will be a one-week washout period between treatments. At the same time each morning and evening (approx. 12 h apart) for one week, subjects will be required to intranasally apply one actuation (40 mg) of either mannitol (contained within a gelatin capsule) or placebo (gelatin capsule containing 40mg lactose) to each nostril using a dry powder inhaler device (Teijen spray applicator). All capsules will be weighed prior to and after each inhalation to check compliance and to determine the actual amount of mannitol delivered.
Locations(1)
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ACTRN12605000473662