A 12 week prospective study of efficacy and acceptability of magnesium sulfate once weekly in adults as a management regime for constipation.
Colocap Pharmaceuticals Pty Ltd
100 participants
Sep 6, 2008
Interventional
Conditions
Summary
The aim of the study is to determine how well a once-weekly dose of Colocap Balance (magnesium sulfate) works in the treatment of chronic constipation. The study hypothesis is that a single, weekly dose of capsules, sufficient to create a strong urge to open the bowel and empty the bowel, will lead to an improvement in constipation symptoms, allow for a reduction in laxative use, and encourage the bowel to start working spontaneously between doses.
Eligibility
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Interventions
Intervention: Encapsulated magnesium sulfate. Capsules containing dried magnesium sulfate, an osmotic laxative which draws water into the bowel making it easy to pass stool. Individual dosage will vary according to need, but will range between 5-45 capsules, and average between 10-20 capsules. Each capsule contains 950mg of magnesium sulfate. The dosage will be taken orally, once weekly for 12 weeks.
Locations(1)
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ACTRN12609000081213