A pilot trial assessing the effect of fish oil on leptin and adiponectin levels in overweight/obese individuals.

This study is looking at whether taking a high-dose fish oil supplement (4,000 mg per day for 8 weeks) can change the levels of two important hormones — adiponectin and leptin — in overweight or obese adults. These hormones are linked to body fat and heart health. This is a pilot study to explore whether fish oil might help improve metabolic health in people who are overweight. You may be eligible if: - You are 18 years of age or older - Your body mass index (BMI) is 25 or greater (overweight or obese) - You are generally healthy You may NOT be eligible if: - You currently take other medications or are participating in another study - You have lost more than 10% of your body weight in the past 6 months - You smoke - You are pregnant or breastfeeding - You have an allergy to fish oil - You take anticoagulants (blood thinners) or the statin medication Pravastatin - You have a major health condition - You have a history of alcohol or drug dependency Talk to your doctor about whether this trial might be right for you.