Cardiovascular Disease Clinical Trials

539 recruitingLast updated: June 17, 2026

There are 539 actively recruiting cardiovascular disease clinical trials across 74 countries. Studies span Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1, Early Phase 1. Top locations include Boston, Massachusetts, United States, Seoul, South Korea, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Cardiovascular Disease Trials at a Glance

539 actively recruiting trials for cardiovascular disease are listed on ClinicalTrialsFinder across 6 cities in 74 countries. The largest study group is Not Applicable with 213 trials, with the heaviest enrollment activity in Boston, Seoul, and New York. Lead sponsors running cardiovascular disease studies include National Heart, Lung, and Blood Institute (NHLBI), University of Alabama at Birmingham, and VA Office of Research and Development.

Browse cardiovascular disease trials by phase

Treatments under study

About Cardiovascular Disease Clinical Trials

Looking for clinical trials for Cardiovascular Disease? There are currently 98 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cardiovascular Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cardiovascular Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 539 trials

Recruiting

Diabetes and Heart Disease Risk in Blacks

ObesityCardiovascular DiseasesHypertension+1 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2,000 enrolled1 locationNCT00001853
Recruiting

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

Cardiovascular DiseaseUndiagnosed Diseases
National Heart, Lung, and Blood Institute (NHLBI)10,000 enrolled1 locationNCT02543996
Recruiting
Phase 1

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

Cardiovascular Disease
National Heart, Lung, and Blood Institute (NHLBI)64 enrolled1 locationNCT04216342
Recruiting
Not Applicable

Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVD

Cardiovascular DiseasesAtherosclerosisDyslipidemia+2 more
Yonsei University1,952 enrolled1 locationNCT07524101
Recruiting

Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)

Cardiovascular DiseasesCardiovascular Risk Factor
University Hospitals, Leicester9,500 enrolled1 locationNCT04388943
Recruiting

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

HypertensionCardiovascular DiseaseAdrenal Gland Neoplasm+2 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1,150 enrolled1 locationNCT03374215
Recruiting
Phase 3

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

HypertensionHigh Risk Cardiovascular DiseaseHigh Cardiovascular Risk
Alnylam Pharmaceuticals11,000 enrolled856 locationsNCT07181109
Recruiting

Measurements Before and After Participation in a Health Intervention Programme in Halsnaes Municipality

Chronic Obstructive Pulmonary Disease (COPD)Cardiovascular DiseaseType 2 Diabetes
Steno Diabetes Center Copenhagen194 enrolled1 locationNCT07641309
Recruiting
Phase 2

Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

Cardiovascular Disease
National Heart, Lung, and Blood Institute (NHLBI)110 enrolled1 locationNCT03372733
Recruiting
Phase 3

Pelacarsen Roll-over Extension Program

Atherosclerotic Cardiovascular Disease
Novartis Pharmaceuticals599 enrolled97 locationsNCT06875973
Recruiting
Not Applicable

The PREBEAT Trial: Digital PREhaBilitation in thE Cardiac Surgical populATion

Cardiovascular Diseases
Claire Hines40 enrolled1 locationNCT06983808
Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting
Not Applicable

Effectiveness and Adoption of the TelTex4BP Intervention Among Adults With Hypertension in Nepal

Cardiovascular DiseasesHypertensionBlood Pressure+1 more
Central Department of Public Health500 enrolled2 locationsNCT05979168
Recruiting

Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infection by Covid-19.

COVID-19 pneumoniaCardiovascular DiseasesPneumonia, Community-Acquired
Hellenic Institute for the Study of Sepsis650 enrolled18 locationsNCT06601998
Recruiting
Phase 3

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

Cardiovascular DiseasesHypertensionDiabetes Mellitus, Type 2
Boehringer Ingelheim11,800 enrolled1155 locationsNCT07064473
Recruiting

Medtronic SYMBIOSIS Post-Market Registry for Patients Undergoing Cardiac Surgery

Cardiovascular Diseases
Medtronic Cardiac Surgery5,000 enrolled14 locationsNCT04241328
Recruiting
Not Applicable

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Heart FailureCardiovascular DiseasesPulmonary Hypertension+1 more
Abbott Medical Devices850 enrolled68 locationsNCT06526195
Recruiting
Phase 3

An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

Cardiovascular Disease and Lipoprotein(a)
Novartis Pharmaceuticals5,700 enrolled618 locationsNCT07517263
Recruiting
Not Applicable

A Digital Lifestyle Intervention in Primary Healthcare to Prevent Cardiovascular Disease

Cardiovascular DiseasesLifestyle Factors
Karolinska Institutet1,000 enrolled6 locationsNCT06847633