Cardiovascular Disease Clinical Trials

91 recruiting

Cardiovascular Disease Trials at a Glance

485 actively recruiting trials for cardiovascular disease are listed on ClinicalTrialsFinder across 6 cities in 74 countries. The largest study group is Not Applicable with 187 trials, with the heaviest enrollment activity in Boston, Seoul, and New York. Lead sponsors running cardiovascular disease studies include National Heart, Lung, and Blood Institute (NHLBI), University of Alabama at Birmingham, and NYU Langone Health.

Browse cardiovascular disease trials by phase

Treatments under study

About Cardiovascular Disease Clinical Trials

Looking for clinical trials for Cardiovascular Disease? There are currently 91 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cardiovascular Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cardiovascular Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 485 trials

Recruiting
Phase 2Phase 3

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis

Atherosclerotic Cardiovascular Disease
CSL Behring2,310 enrolled542 locationsNCT05485961
Recruiting

Diabetes and Heart Disease Risk in Blacks

ObesityCardiovascular DiseasesHypertension+1 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2,000 enrolled1 locationNCT00001853
Recruiting

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

ObesityCardiovascular Disease
National Heart, Lung, and Blood Institute (NHLBI)200 enrolled1 locationNCT01927783
Recruiting
Phase 3

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

Cardiovascular Disease
Amgen11,000 enrolled243 locationsNCT07136012
Recruiting

Awareness of Risk Factors and Perception of Cardiovascular Risk in Secondary Prevention Among Women and Men

Cardiovascular Disease
Istituti Clinici Scientifici Maugeri SpA200 enrolled1 locationNCT07521436
Recruiting
Phase 3

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

Cardiovascular DiseasesHypertensionDiabetes Mellitus, Type 2
Boehringer Ingelheim11,800 enrolled1152 locationsNCT07064473
Recruiting

Hypertension Explored in Long-term Postpartum Follow-up in Later Life

Cardiovascular DiseasesHypertensionCerebrovascular Disorders+1 more
University of Oxford200 enrolled1 locationNCT06187012
Recruiting
Not Applicable

SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation

Cardiovascular DiseasesCardiac Rehabilitation
The Miriam Hospital400 enrolled1 locationNCT06886789
Recruiting

Identifying Risk Factors and Predicting Future Health Outcomes for Korean Patients With Heart and Blood Vessel Diseases: A Long-term Follow-up Study

Cardiovascular Diseases (CVD)Cerebro Vascular Disease
Samsung Medical Center800,000 enrolled1 locationNCT07393412
Recruiting

Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in Sub-Saharan Africa

ObesityCardiovascular DiseasesChronic Kidney Diseases+8 more
Swiss Tropical & Public Health Institute1,200 enrolled1 locationNCT05881447
Recruiting

Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank

Williams SyndromeCardiovascular DiseaseSupravalvular Aortic Stenosis
National Heart, Lung, and Blood Institute (NHLBI)1,099 enrolled3 locationsNCT02706639
Recruiting

Cardiovascular Health Improvement Project

Heart FailureCardiovascular DiseasesAortic Aneurysm+2 more
University of Michigan15,000 enrolled1 locationNCT02306200
Recruiting

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

Cardiovascular DiseaseUndiagnosed Diseases
National Heart, Lung, and Blood Institute (NHLBI)10,000 enrolled1 locationNCT02543996
Recruiting
Phase 2

Efficacy, Safety, and PopPK Profile of ABP-745 in Patients With Atherosclerosis

ASCVDAtherosclerosis Cardiovascular DiseaseASCVD Management
Atom Therapeutics Co., Ltd200 enrolled33 locationsNCT07303777
Recruiting

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

HypertensionCardiovascular DiseaseAdrenal Gland Neoplasm+2 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1,150 enrolled1 locationNCT03374215
Recruiting
Phase 3

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

ObesityOverweightAtherosclerotic Cardiovascular Disease
Amgen12,800 enrolled759 locationsNCT07037433
Recruiting

Fascial Plane Blocks and Quality of Recovery in Cardiac Surgery

Pain, PostoperativeCardiovascular DiseasesCardiovascular Surgical Procedures
Ordu University123 enrolled1 locationNCT07557108
Recruiting

Mayo AVC Registry and Biobank

CardiomyopathiesCardiovascular DiseasesHeart Diseases+5 more
Mayo Clinic1,000 enrolled2 locationsNCT03049254
Recruiting

Oral Microbiome in Carotid Atherosclerosis

PeriodontitisAtherosclerosis Cardiovascular DiseaseAtherosclerosis of Artery+2 more
Semmelweis University Heart and Vascular Center200 enrolled1 locationNCT07296965
Recruiting

Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation

Cardiovascular DiseasesHypertensionVascular Diseases
Medtronic Vascular1,000 enrolled1 locationNCT07174622