RecruitingPhase 4ACTRN12612000700831

Role of oral ketamine and dexmedetomidine in adults burns dressing. A double blind randomised cross over study.

Role of oral ketamine and dexmedetomidine in adults burns dressing for evaluating safety and efficacy:A double blind randomised cross over study

Sponsor

Jawaharlal Nehru institute of Medical education and research

Enrollment

45 participants

Start Date

Aug 1, 2010

Study Type

Interventional

Conditions

Burns

Summary

To evaluate the analgesic effect and safety of dexmedetomidine and ketamine in adults during burns dressing changes

Eligibility

Sex: Both males and femalesMin Age: 15 YearssMax Age: 40 Yearss

Plain Language Summary

Simplified for easier understanding

This study tests two medications — ketamine and dexmedetomidine — given by mouth to reduce pain during burn wound dressing changes in adult patients. Changing burn dressings is very painful, and current pain medications do not always work well. The study aims to find out which medication (or combination) works better and is safer. You may be eligible if: - You are 15 to 40 years old - You have burns covering 20 to 50% of your body surface area - You can take medications by mouth You may NOT be eligible if: - You have burns on your face that prevent you from swallowing oral medications Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Patients will be given morphine intra muscular( IM) 0.1 mg/kg;; local anesthetic soaked gauzes will be applied on the wounds oral ketamine 5 mg/kg will be given ;visual analogue scale( VAS) score; sedation score; vital parameters will be recorded; the next day patient cross over to dexmedetomidine group; they will receive morphine similar to the previous day and dexmedetomidine 4ug/kg all the above parameters recorded