RecruitingACTRN12612001100886

Using cardiac magnetic resonance imaging to detect early changes in heart muscle that may help predict patients who are at risk of developing toxicity from anthracycline chemotherapy.

Use of myocardial tissue characterization by cardiac magnetic resonance imaging to predict left ventricular dysfunction in patients undergoing anthracycline chemotherapy.


Sponsor

Dr James Hare

Enrollment

50 participants

Start Date

Oct 12, 2012

Study Type

Observational

Conditions

Summary

Aim is to assess whether a novel cardiac magnetic resonance imaging (CMR) technique, T2 mapping, can identify myocardial edema as a marker of myocardial injury and be used as a predictor of cardiac dysfunction in patients undergoing anthracycline chemotherapy.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 90 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether a special type of heart MRI (called T2 mapping) can detect early damage to the heart muscle caused by anthracycline chemotherapy — a type of cancer treatment used for conditions like lymphoma. Anthracyclines can sometimes harm the heart, but this damage often isn't detected until the heart has already weakened significantly. Researchers hope that T2 mapping can spot early warning signs by detecting swelling in the heart muscle, allowing doctors to step in earlier to protect patients. You may be eligible if: - You are between 18 and 90 years old - You have been referred for anthracycline chemotherapy (for example, for lymphoma) - OR you are a healthy volunteer acting as a comparison participant You may NOT be eligible if: - Your kidneys are not working well enough (GFR below 60 mL/kg/1.73m²) - You have a reason you cannot have an MRI scan - You are allergic to gadolinium (MRI contrast dye) - You have atrial fibrillation at the start of the study - You are pregnant Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Magnetic resonance imaging scan of the heart (60 minutes duration) before chemotherapy, on completion of chemotherapy cycles (~3 months) and at 1 year after commencement of chemotherapy.We will use no

Magnetic resonance imaging scan of the heart (60 minutes duration) before chemotherapy, on completion of chemotherapy cycles (~3 months) and at 1 year after commencement of chemotherapy.We will use novel MRI sequences (T1 and T2 mapping) which aim to quantify specific magnetic properties of the heart muscle that related to myocardial edema (seen in inflammation) and fibrosis.


Locations(1)

Australia

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