RecruitingPhase 1Phase 2NCT07302347

A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21)

A Phase I/II Study of Pembrolizumab (MK-3475) in Japanese Pediatric Participants With Specific Solid Tumors or Lymphomas, or in Japanese Adult Participants With Advanced Merkel Cell Carcinoma (KEYNOTE-G21)


Sponsor

Merck Sharp & Dohme LLC

Enrollment

20 participants

Start Date

Jun 30, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Researchers are looking for new ways to treat people with solid tumors, lymphomas (blood cancers), and a certain type of skin cancer. The goals of this study are to learn: * About the safety of pembrolizumab (the study medicine) and if people tolerate it * What happens to different doses of pembrolizumab in a person's body over time * How the cancer responds (gets smaller or goes away) to treatment


Eligibility

Min Age: 6 Months

Plain Language Summary

Simplified for easier understanding

This study is examining how an immunotherapy drug called pembrolizumab (Keytruda) works in Japanese children and teenagers with certain blood cancers or solid tumors, as well as Japanese adults with a rare skin cancer called Merkel cell carcinoma. It aims to confirm the drug's effectiveness and safety in these specific populations. **You may be eligible if...** - You are a Japanese child or young person with relapsed/refractory classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, certain solid tumors, or completely resected high-risk melanoma - OR you are a Japanese adult with Merkel cell carcinoma (a rare but aggressive skin cancer) - Your cancer has been confirmed by standard diagnostic tests - You have measurable disease or meet other specified criteria depending on your cancer type **You may NOT be eligible if...** - You have already received pembrolizumab or a similar checkpoint inhibitor drug - You have active autoimmune disease requiring systemic treatment - You have untreated brain metastases - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALPembrolizumab

25 mg/mL solution for intravenous infusion.


Locations(4)

Nagoya City University Hospital ( Site 0003)

Nagoya, Aichi-ken, Japan

Sapporo Hokuyu Hospital ( Site 0005)

Sapporo, Hokkaido, Japan

National Cancer Center Hospital ( Site 0002)

Chūō, Tokyo, Japan

National Hospital Organization Kyushu Cancer Center ( Site 0001)

Fukuoka, Japan

View Full Details on ClinicalTrials.gov

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NCT07302347


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