RecruitingPhase 2ACTRN12613001121752

Effect of Cabergoline on biochemical and anthropometric parameters of patient with Impaired Glucose metabolism (Impaired Fasting Glucose/Impaired Glucose Tolerance)

Effect of Cabergoline Vs placebo on HbA1C, HOMA-IR, HOMA-Beta, FPG, anthropometric parameters in patient with Impaired fasting glucose/Impaired glucose tolerance.


Sponsor

Shahid Beheshti University of Medical Sciences

Enrollment

70 participants

Start Date

Jul 1, 2013

Study Type

Interventional

Conditions

Summary

Impaired Glucose metabolism has no treatment and only life style modification could stop progression of this condition to diabetes, so we want to try effect of cabergoline in this condition to alleviate metabolic impairment and progression to diabetes.


Eligibility

Sex: Both males and femalesMin Age: 20 YearssMax Age: 65 Yearss

Plain Language Summary

Simplified for easier understanding

This study tests whether a medication called cabergoline can help people with pre-diabetes — blood sugar levels that are higher than normal but not yet high enough to be called diabetes — avoid developing full type 2 diabetes. Pre-diabetes usually has no treatment besides lifestyle changes, but many people still progress to diabetes. Cabergoline works on the brain's dopamine system and may help improve blood sugar, insulin sensitivity, and other metabolic measurements. Researchers will track body weight, blood sugar levels, and other health markers over the course of the study. You may be eligible if: - You are between 20 and 65 years old - You have been told your blood sugar is in the pre-diabetes range (fasting glucose 100–110 mg/dL, or 2-hour glucose after a glucose tolerance test between 140–199 mg/dL) - You are male or female You may NOT be eligible if: - You have serious liver disease - You have fibrotic disorders affecting the lungs, heart valves, or abdomen - You are allergic to ergot-derived medications - You have uncontrolled high blood pressure - You have diabetes (not just pre-diabetes) - You are pregnant or breastfeeding - You have a major psychiatric disorder or an eating disorder (bulimia or anorexia) Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

addition of Cabergoline 0.5 mg oral tabletes twice weekly for 4 month or placebo in patients with prediabetes receiving a balanced diet, to to measure patient compliance to Cabergoline, tablet returne

addition of Cabergoline 0.5 mg oral tabletes twice weekly for 4 month or placebo in patients with prediabetes receiving a balanced diet, to to measure patient compliance to Cabergoline, tablet returned counted at the final visit, in addition to comparing thr prolactin level of every patient.


Locations(1)

Tehran, Iran, Islamic Republic Of

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