Prediabetes Clinical Trials

115 recruitingLast updated: June 18, 2026

There are 115 actively recruiting prediabetes clinical trials across 30 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1. Top locations include Bialystok, Podlaskie Voivodeship, Poland, Brooklyn, New York, United States, Baltimore, Maryland, United States. Updated daily from ClinicalTrials.gov.


Prediabetes Trials at a Glance

115 actively recruiting trials for prediabetes are listed on ClinicalTrialsFinder across 6 cities in 30 countries. The largest study group is Not Applicable with 81 trials, with the heaviest enrollment activity in Bialystok, Brooklyn, and Baltimore. Lead sponsors running prediabetes studies include Mayo Clinic, Medical University of Bialystok, and University Hospital Tuebingen.

Browse prediabetes trials by phase

Treatments under study

About Prediabetes Clinical Trials

Looking for clinical trials for Prediabetes? There are currently 117 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Prediabetes trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Prediabetes clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 115 trials

Recruiting
Not Applicable

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Metabolic SyndromeDiabetes Mellitus, Type 2Prediabetes
Cleerly, Inc.7,500 enrolled124 locationsNCT06112418
Recruiting

Personality Traits and Biochemical Risk Phenotypes

Metabolic SyndromePrediabetesHyperglycemia
Medical Center TOPMED1,000 enrolled1 locationNCT07653048
Recruiting
Not Applicable

Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

PrediabetesHyperglycaemia (Non Diabetic)
University of Arkansas20 enrolled1 locationNCT06025292
Recruiting
Not Applicable

Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes

PrediabetesMetforminsedentary+2 more
University of Virginia24 enrolled1 locationNCT07131384
Recruiting

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

ObesityInsulin ResistanceMetabolic Disease+2 more
University of Michigan175 enrolled1 locationNCT06007404
Recruiting
Not Applicable

Effect of Increased Physical Activity and Stopping Evening Snacking in Metabolic Health in Youth With Prediabetes

Prediabetes
Baylor College of Medicine80 enrolled1 locationNCT06782906
Recruiting
Not Applicable

Fiber mHealth Intervention for Prediabetes

Prediabetes
University of Oklahoma80 enrolled1 locationNCT07491653
Recruiting
Not Applicable

The Effect of Time-Restricted Eating in Cardiometabolic Health

ObesityPrediabetes
Cambridge University Hospitals NHS Foundation Trust100 enrolled1 locationNCT05866406
Recruiting
Not Applicable

Personalized Meal Timing and Walking Based on Glucose Patterns in Adults With Prediabetes

PrediabetesPrediabetes (Insulin Resistance, Impaired Glucose Tolerance)Prediabetes or Diabetes
Shifa International Hospital105 enrolled1 locationNCT07618663
Recruiting
Not Applicable

Cardiometabolic Effects of Pecan Snacking in Prediabetes

Prediabetes
Penn State University147 enrolled1 locationNCT07235358
Recruiting

Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.

Prediabetes / Type 2 Diabetes
Angelina Passaro150 enrolled2 locationsNCT07602023
Recruiting
Not Applicable

Smartwatch-based Intervention for Cardiovascular Health (SWITCH)

PrediabetesPrehypertensionOverweight/Obesity+1 more
Beijing Anzhen Hospital1,400 enrolled3 locationsNCT07372729
Recruiting
Not Applicable

Diabetes Clinical Decision Support

DiabetesPrediabetesHyperglycemia+2 more
Milton S. Hershey Medical Center15,732 enrolled2 locationsNCT05447806
Recruiting
Not Applicable

Night Owl Metabolism

OverweightPrediabetesImpaired Glucose Tolerance
Johns Hopkins University70 enrolled1 locationNCT06507722
Recruiting
Not Applicable

Basic Carbohydrate Counting in Prediabetes

Prediabetes
Hamide Sahin120 enrolled1 locationNCT07525622
Recruiting

Pharmacist-Led Continuous Glucose Monitoring for Prediabetes

Prediabetes
University of South Florida40 enrolled2 locationsNCT07529366
Recruiting
Not Applicable

CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes

Prediabetes
State University of New York at Buffalo214 enrolled1 locationNCT07140848
Recruiting
Not Applicable

Intermittent Fasting to Improve Insulin Secretion

PrediabetesDiabetes type2Intermittent Fasting+1 more
University Hospital Tuebingen200 enrolled8 locationsNCT04607096
Recruiting
Not Applicable

Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes

Prediabetes
Mayo Clinic60 enrolled1 locationNCT06424106
Recruiting
Not Applicable

Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being

AsthmaObesity, OverweightPrediabetes+4 more
Waianae Coast Comprehensive Health Center100 enrolled1 locationNCT07536256