RecruitingACTRN12615000042549

Detection of Individuals with Preclinical, Prodromal and Mild Alzheimer's Disease for Therapeutic Trials.

Detection of Individuals with Preclinical, Prodromal and Mild Alzheimer's Disease optimizing the use of cognitive and blood biomarker findings to increase the rate of amyloid scan positive subjects using Amyloid and Fluorodeoxyglucose Positron Emission Tomography (FDG PET) imaging for Therapeutic trials.

Sponsor

Professor Chris Rowe

Enrollment

450 participants

Start Date

Dec 17, 2014

Study Type

Interventional

Conditions

Mild Alzheimer's Disease Prodromal Alzheimer's Disease Preclinical Alzheimer's Disease

Summary

This study aims to use recent advances in PET scanning techniques, in particular Amyloid scanning to assist in the detection of Preclinical, Prodromal and Mild Alzheimer's disease.

Eligibility

Sex: Both males and femalesMin Age: 50 YearssMax Age: 85 Yearss

Inclusion Criteria6

Mild cognitive impairment or mild Alzheimer's Disease.
> 6years of education.
Adequate English and visual and auditory acuity for psychometric testing.
Able to undergo MRI imaging.
MMSE 20 and above.
An interest in research participation.

Exclusion Criteria3

Other neurodegenerative disorders, severe mental illnesses. History of cancer within the last 5 years (excluding skin or insitu prostate cancer).
Drug and alcohol abuse.
MRI contraindications.

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Interventions

Cognitive assessment will be performed at visits one and four lasting approximately one hour. Blood biomarker sampling will occur at visit 4. The Amyloid PET scan will be done at visit two and invo

Cognitive assessment will be performed at visits one and four lasting approximately one hour. Blood biomarker sampling will occur at visit 4. The Amyloid PET scan will be done at visit two and involves intravenous injection of 200 +/-10%MBq of (18F)Nav4694. A 20-minute scan will be acquired starting at 50 minutes post injection. Where MRI Brain scan results with a 3D sequence from within the past six months are not available, an MRI will be done at visit 2 or visit 3. An FDG PET scan will be done at visit three using an intravenous injection of 185 +/-10% of (18F)FDG. A 15-minute scan will be acquired starting at 30 minutes post injection.