RecruitingNot ApplicableNCT05417555

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

Modulation of Hippocampal Circuitry and Memory Function With Focused Ultrasound in Amnestic MCI


Sponsor

University of California, Los Angeles

Enrollment

144 participants

Start Date

Sep 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The main questions the study seeks to answer are: 1. Can LIFUP increase brain activity in the targeted area? 2. Can LIFUP improve memory in people with MCI and mild AD? 3. Can LIFUP improve connectivity of memory networks in the brain? Participants in this study will complete MRIs and memory testing, and receive Low Intensity Focused Ultrasound to a part of their brain involved in memory (the entorhinal cortex).


Eligibility

Min Age: 50 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether low-intensity focused ultrasound — a non-invasive brain stimulation technique — can improve memory and thinking in people with mild cognitive impairment or early Alzheimer's disease. Unlike medication, this approach uses sound waves targeted at specific brain areas. **You may be eligible if...** - You have been diagnosed with amnestic mild cognitive impairment (MCI) or mild Alzheimer's disease - You are between 50 and 90 years old - You are an English speaker - You are able to give informed consent on your own - You have normal or corrected vision and hearing **You may NOT be eligible if...** - You are currently enrolled in another clinical trial - You are taking immunotherapy medications for Alzheimer's - You have metal implants in your head or a pacemaker - You have a history of seizures, stroke, or significant brain injury - You have severe depression, anxiety, or another major psychiatric condition - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICELow-Intensity Focused Ultrasound Pulsation (LIFUP)

Low intensity focused ultrasound pulsation will be administered to the left entorhinal cortex at 650kHz, ispta.3 720mW/cm, pulse repetition frequency 100Hz, duty cycle 50%, duration 30s with 30s spacing between sonications, 6 sonications per dose (participants receive 0, 1, 2 or 3 doses depending on group assignment)


Locations(1)

UCLA Semel Institute for Neuroscience and Behavior

Los Angeles, California, United States

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NCT05417555


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