Development of a method for describing lactate kinetics in ICU patients – a pilot study in healthy volunteers.
Development of a method for describing lactate kinetics in ICU patients using a stable labeled 13C-lactate bolus – a pilot study in healthy volunteers.
Karolinska University Hospital
6 participants
Jan 13, 2017
Interventional
Conditions
Summary
In order to study lactate kinetics in ICU patients with a minimally invasive technique we are performing this pilot study on healthy volunteers. After a standard health form, medical examination and testing the fasting subjects will receive venous and arterial catheters. Base line samples are drawn and frozen. A bolus of stable isotopically labeled 13C-lactate will be given (2.7mg/kg body weight). Blood samples will be drawn at 37 time points throughout 2 hours (not more than 100ml blood al together). Samples will be analyzed at bedside analyzer and snap frozen for later analysis for relationship between 13C-labelled and normal lactate. Subjects will monitored with ECG, pulsoximetry and blood pressure throughout the experiment.
Eligibility
Plain Language Summary
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Interventions
Healthy volunteers will receive a peripheral venous catheter and an arterial catheter. They will then receive a bolus of 13-labelled lactate (2.7mg/kg) and blood samples will be drawn continuously during the next two hours (not more than 100ml blood will be drawn).
Locations(1)
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ACTRN12617000310369