RecruitingNCT07345169

IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients

Studies on the Immunological and Inflammatory Determinants Associated With the Prognosis of Patients Admitted to Intensive Care

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

540 participants

Start Date

Jan 1, 2026

Study Type

OBSERVATIONAL

Conditions

Intensive care patients Critical Illness Critical Illness Requiring Intensive Care - Sepsis Critical Illness Requiring Intensive Care - Acute Brain Injury Critical Illness Requiring Intensive Care - Major Surgery Critical Illness Requiring Intensive Care - Polytrauma

Summary

This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU). The study will establish multidimensional models predicting one-year survival and the occurrence of nosocomial infections. Patients admitted to ICU undergo routine biological sampling. In addition to these, minimal supplementary samples will be collected for immunological and inflammatory biomarker analysis at admission, day 1, day 4, day 8, ICU discharge or day 28, and at 12 months. Additional samples may be taken during clinically significant events (nosocomial infections, complications).

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Age ≥ 18 years
Admission to ICU within 24 hours

Exclusion Criteria7

Moribund patient (ECOG=4)
Legal protection (guardianship/curatorship)
Uninsured patients
Pre-existing immunosuppression (active/recent cancer, hematologic disease, autoimmune disease, organ transplant, HIV)
Pregnant or breastfeeding women
Participation in another interventional trial
Patients under AME