Comparing the miss rate of detecting adenoma using 2 imaging techniques during colonoscopy
Linked color imaging versus white light: a randomised tandem colonoscopy study of adenoma miss rates
Queen Elizabeth II Jubilee Hospital
100 participants
Apr 10, 2017
Interventional
Conditions
Summary
The primary purpose of this trial is to evaluate the efficiency of two endoscopic imaging techniques for detecting colonic adenoma during colonoscopy. Who is it for? You may be eligible to enroll in this trial if you are aged 18 or over, and are scheduled to undergo a colonoscopy. Study details All participants enrolled in this trial will receive colonoscopy using both standard white light (WL) and linked colour imaging (LCI). LCI is a new endoscopic image enhancement technology that is built-in within scopes and activated by a push-button and highlight mucosal abnormalities within the gastrointestinal lumen. LCI uses different band widths and filters and is hypothesized to improve detection of subtle gastrointestinal pathology. Participants will be randomly allocated (by chance) to receive WL imaging first, followed immediately by LCI to detect any polyps missed by WL, or to receive LCI imaging first, followed immediately by WL to detect any polyps missed by LCI. This will allow researchers to investigate which technique results in less missed adenomas during colonoscopy.
Eligibility
Plain Language Summary
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Interventions
Interventional Procedure (Arm 1): Initial inspection with linked colour imaging (LCI) then white light (WL) The procedure will be performed by qualified gastroenterologists (who also underwent additional advanced therapeutic colonoscopy training). They are A/Prof David Hewett (FRACP), Dr Nicholas Tutticci (FRACP) and Dr Ammar Kheir (FRACP). The duration of the total procedure time will be approximately 30 - 40 minutes. Keeping in mind that insertion time to the caecum will average 5 minutes with minimum 6 minutes withdrawal time (as per national standard) for each insertion. The device used is the new is the 7000 'Trademark' endoscopic system powered by Fujifilm’s unique 4-LED Multi Light 'Trademark' technology sets a new standard in light intensity and endoscopic imaging (this is equivalent to the European model ELUXEO 'Trademark'). The white light (WL) is essentially a high definition normal white light without manipulation of the normal light wavelengths. The Linked-colour imaging (LCI) creates clear and bright endoscopic images using short wavelength witha narrow-band light that enhances the vessels in on the mucosal surface and patterns of the mucosa (410-nm and 450-nm wavelengths with a bandwidth that is <2nm), A research assistant will measure insertion and withdrawal times by using a stopwatch. On insertion, the stopwatch will be started at the moment the rectal mucosa is visualised, and timing will be continued until the colonoscope tip has entered the caecal caput. On withdrawal, mucosal inspection will be performed firstly using linked colour imaging until withdrawn to the rectum. Polyps will be removed as they are identified (via standard polypectomy techniques) and each polyp submitted separately for pathological examination. Reinsertion will then be performed to the caecum and further mucosal inspection performed using white light until withdrawn to the rectum. Further detected polyps will be removed as they are identified (via standard polypectomy techniques) and each polyp submitted separately for pathological examination.
Locations(1)
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ACTRN12617000521325