Elucidating the Effects of Tocotrienol rich Vitamin E on Metabolic Biomarkers in a Pre-diabetes Population in Malaysia.

Pre-diabetes is a stage where blood sugar levels are higher than normal but not yet high enough to be called type 2 diabetes. Without intervention, many people with pre-diabetes go on to develop full diabetes. Vitamin E — specifically a form called tocotrienol — has shown early promise in improving how the body responds to insulin, but more evidence is needed. This Malaysian study is testing whether taking 200mg per day of tocotrienol-rich Vitamin E supplements helps to improve insulin sensitivity and blood sugar control in people with pre-diabetes. Half of participants will receive the supplement and half will receive a dummy pill (placebo), and neither participants nor researchers will know who received which until the study ends. You may be eligible if you are between 40 and 75 years old, are of Malaysian Chinese, Malay or Indian background, have a pre-diabetes HbA1c reading of 5.7–6.4%, and score 15 or above on a diabetes risk assessment tool. People with established diabetes for 5+ years, poorly controlled blood pressure, pregnancy, serious illness, kidney disease, or who are currently taking other vitamin supplements are not eligible.