The effect of topical flavanoid cream on post-operative excisional haemorrhoidectomy pain; a randomised controlled trial
The effectiveness of Topical Micronized Purified Flavonoid Fraction Post Excisional Haemorrhoidectomy on Pain: A Double-Blinded Randomised Controlled Trial in Adult patients.
University of Auckland
120 participants
Feb 1, 2026
Interventional
Conditions
Summary
The purpose of this trial is test whether a new medication containing a plant based product MPPF, will reduce the amount of pain patients experience following an excisional haemorrhoidectomy. Evidence suggests there may be a reduction of pain following administration of oral MPPF, however there is no evidence to support the use of a topical formulation. We hypothesize that our cream will reduce the amount of pain patients report following excision of haemorrhoids, adding to a growing number of analgesic options for a very common problem seen worldwide.
Eligibility
Inclusion Criteria4
- Adult patients 18 years and over undergoing excisional haemorrhoidectomy of any type (open, closed)
- Grade III or IV haemorrhoids
- Willing and able to provide informed consent
- Able to apply topical treatments independently
Exclusion Criteria7
- Patient’s <18 years
- Haemorrhoids grade I or II
- Concurrent perianal pathology – fissure, fistulas, ulcers etc
- Known allergy or adverse drug reaction to metronidazole or lignocaine
- Pregnant or breastfeeding women
- Patients with history of chronic pain
- Patients unable to consent due to cognitive impairment or language barrier where an interpreter is unavailable
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Interventions
Intervention drug is a topical cream composed of 10% metronidazole (antibiotic), 4% lignocaine (local anaesthetic), and 5% micronized purified flavanoid fraction (MPFF). This will be taken for 1 week, three times per day. Applied morning following surgery. The tubes will be collected and weighed to measure adherence at follow up. The application of a topical cream composed of 10% metronidazole (antibiotic), 4% lignocaine
Locations(1)
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ACTRN12625001130459