Response to frusemide in critically ill patients requiring dialysis

When patients in the intensive care unit develop severe kidney injury, they often need continuous dialysis (a form of kidney replacement therapy called CRRT) to keep them alive. But knowing the right time to stop dialysis — once the kidneys start to recover — is tricky. Stopping too early can be harmful, but continuing dialysis longer than necessary can also cause problems. This study is exploring whether a simple test called the furosemide stress test (FST) — giving a dose of furosemide, a common diuretic, and measuring how much urine the patient produces in response — can help doctors judge when a patient's kidneys have recovered enough to stop dialysis. This early-phase study will assess what proportion of ICU patients respond to the test, and whether a larger future trial to guide this decision is feasible. You may be eligible if you are 18 or older, are in the ICU receiving continuous dialysis for kidney injury (or have had it paused for under 12 hours), have been on dialysis for more than 24 hours, and your vital signs and fluid balance are stable. People with a known allergy to furosemide, end-stage kidney disease, or who are pregnant or breastfeeding are not eligible.