RecruitingNCT00710112

Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants

Sponsor

Medical College of Wisconsin

Enrollment

1,100 participants

Start Date

Jun 1, 2006

Study Type

OBSERVATIONAL

Conditions

Chronic Lung Disease

Summary

The purpose of this study is to determine if sequence variations in genes involved in the development and function of vulnerable organs increases susceptibility to chronic lung disease (CLD) and other diseases affecting premature infants, such as necrotizing enterocolitis (NEC), sepsis, patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH). The study will also determine whether measurement of certain biomarkers in serum will identify infants who will develop these complications of prematurity. Previous studies from this institution and others have identified genetic variants in some genes, such as toll like receptor genes are associated with higher risk of CLD or NEC. The interaction of these variants with other gene variants that can influence the risk of these diseases remains unclear.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study is investigating how differences in genes might make some very small premature babies more susceptible to serious conditions like respiratory distress syndrome, necrotizing enterocolitis (an intestinal disease), and retinopathy of prematurity (eye disease). The goal is to understand genetic risk factors so that premature infants can be better protected. You may be eligible if: - You are an infant born weighing less than 1,500 grams (about 3.3 pounds) You may NOT be eligible if: - You have a congenital heart defect other than a patent ductus arteriosus (PDA) - You have a major birth defect of the gastrointestinal tract, respiratory tract, or kidneys Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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