Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes
Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes Mellitus Undergoing Coronary Revascularisation
Barts & The London NHS Trust
250 participants
Jun 24, 2009
OBSERVATIONAL
Conditions
Summary
Patients living with diabetes mellitus have double the risk of kidney failure compared to patients without diabetes following use of dye in many x-rays and procedures to diagnose and treat narrowing of the arteries (blood vessels) in the heart that can lead to angina or a heart attack. Heart disease is the commonest cause of death in patients with diabetes. People with diabetes are more likely to need these tests/treatments. By identifying those at greater risk of kidney complications we may be able to make these tests/treatments safer and offer them to more patients with diabetes.
Eligibility
Inclusion Criteria7
- Age > 18 years, known diabetes mellitus or BM on arrival consistent with probable diagnosis of diabetes, eGFR <60 ml/min
- Undergoing a PCI procedure
- Agrees to the additional collection of blood and urine samples as outlined above
- Agrees to access of their clinical records for the collection of relevant medical data
- No history or signs of drug abuse
- Able to understand and sign the written Informed Consent Form
- Able and willing to follow the Protocol requirements
Exclusion Criteria5
- Cardiogenic shock
- Pregnancy
- Patient on renal replacement therapy (haemodialysis/CAPD/renal transplant)
- Known clinically significant infection such as HIV, Hepatitis or TB
- Any patient determined not able to make a reasoned, informed consent prior to the planned interventional procedure
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Locations(1)
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NCT00948116