COsegregation of VARiants in Panel of Genes
Study of Family COsegregation of Nucleotide VARiants in the Panel of Genes to Validate Their Use in Genetic Counseling
Institut Curie
3,500 participants
Jul 2, 2012
INTERVENTIONAL
Conditions
Summary
The aim of the COVAR project is to classify reliably a maximum of VUS of the French database in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.
Eligibility
Inclusion Criteria9
- Index cases:
- A person carrying a gene variant class 3 or 4, present and selected in the families of national database of genetic group and cancer (GGC Unicancer) which identifies the variations of all genes from the panel of genes of all French laboratories.
- Age ≥ 18 years.
- Signed written inform consent "index case"
- Related parties:
- Any relative of an index case with cancer
- Any relative without cancer related to an index case, retained by investigators, based on family structure and degree of related compared to the index case
- Age ≥ 18 years
- Information and signature of the informed consent "selected relatives"
Exclusion Criteria3
- Minors
- Persons deprived of liberty or under guardianship (including curators).
- Absence of signed written inform consent
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Interventions
The saliva samples will be made of selected related (DNA).
Locations(57)
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NCT01689584