Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

This study collects airway, blood, and urine samples from both healthy people and those with lung diseases to help researchers study how lung conditions develop and find new treatments. **You may be eligible if...** - You are 18 or older, male or female, of any background or smoking status - You are either a healthy volunteer, or you have a diagnosed or suspected lung disease - For those with cystic fibrosis (CF): you must have a specific gene mutation and mild-to-moderate lung function **You may NOT be eligible if...** - Healthy volunteers: you have chronic lung disease, had a recent lung infection in the past 3 months, or are pregnant or nursing - Lung disease volunteers: you are allergic to common medications used during the procedure (such as lidocaine or atropine), or you cannot safely undergo a bronchoscopy (a camera procedure to look inside the airways) - For CF patients: you had a lung flare-up within the past 8 weeks Talk to your doctor to see if this trial is right for you.