Smoking Clinical Trials

239 recruitingLast updated: June 17, 2026

There are 239 actively recruiting smoking clinical trials across 38 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include Charleston, South Carolina, United States, Philadelphia, Pennsylvania, United States, Buffalo, New York, United States. Updated daily from ClinicalTrials.gov.


Smoking Trials at a Glance

239 actively recruiting trials for smoking are listed on ClinicalTrialsFinder across 6 cities in 38 countries. The largest study group is Not Applicable with 149 trials, with the heaviest enrollment activity in Charleston, Philadelphia, and Buffalo. Lead sponsors running smoking studies include Medical University of South Carolina, University of California, San Francisco, and University of Oklahoma.

Treatments under study

About Smoking Clinical Trials

Looking for clinical trials for Smoking? There are currently 96 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Smoking trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Smoking clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 239 trials

Recruiting
Not Applicable

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

COPDSmokingTobacco Use
Philip Morris Products S.A.290 enrolled112 locationsNCT07108166
Recruiting
Not Applicable

A Novel Tobacco Cessation Resource for Smokers With a Diagnosed or Suspected Thoracic Cancer

Cigarette Smoking-Related CarcinomaMalignant Thoracic Neoplasm
Ohio State University Comprehensive Cancer Center30 enrolled1 locationNCT07455513
Recruiting
Not Applicable

CONNECTing to LungCare

Lung CarcinomaSmoking CessationCigarette Smoking-Related Carcinoma
University of California, San Francisco152 enrolled1 locationNCT06213532
Recruiting
Not Applicable

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Tobacco UseCigarette SmokingCigarette Smoking Behavior
Abramson Cancer Center at Penn Medicine472 enrolled1 locationNCT07199517
Recruiting
Not Applicable

Phone Enabled Implementation of Cessation Support

Smoking Cessation
University of Florida1,500 enrolled1 locationNCT05628389
Recruiting
Phase 2

A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

Smoking
Eli Lilly and Company222 enrolled27 locationsNCT07223840
Recruiting
Early Phase 1

Addictive Threshold of Nicotine

smoking addiction
Yale University45 enrolled1 locationNCT06096714
Recruiting
Not Applicable

Neuroimaging of Adolescent Cannabis Use Treatment

Cannabis withdrawalSubstance Use DisordersCannabis Use+23 more
Indiana University80 enrolled1 locationNCT07340554
Recruiting

Functional Capacity, Subjective Dyspnea and Fatigue in Smokers

Smoking
Istinye University107 enrolled1 locationNCT07520981
Recruiting
Phase 2Phase 3

Evaluating Smoking Cessation Interventions for PWH in South Africa

Comorbidities and Coexisting ConditionsSmoking CessationHIV
Johns Hopkins University660 enrolled1 locationNCT05413122
Recruiting
Not Applicable

Cigarette Filter Study

Smoking, Cigarette
Rutgers, The State University of New Jersey252 enrolled1 locationNCT07348679
Recruiting
Not Applicable

Healthy Family Project: Tobacco Use and Smoke Exposure in Asian American Communities

Smoking CessationTobacco-Related Carcinoma
University of California, San Francisco760 enrolled1 locationNCT07049757
Recruiting
Phase 3

Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program

Cigarette Smoking-Related Carcinoma
Alliance for Clinical Trials in Oncology600 enrolled222 locationsNCT05008848
Recruiting

Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers

COPDSmokingTobacco Use
University of California, San Francisco40 enrolled3 locationsNCT04722835
Recruiting
Not Applicable

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

SmokingTobacco
RAI Services Company1,280 enrolled7 locationsNCT07598136
Recruiting
Not Applicable

Reduce Tobacco Use in People Living With HIV in Switzerland

SmokingHIV
University Hospital, Basel, Switzerland972 enrolled7 locationsNCT06789692
Recruiting
Not Applicable

Influence of Authorized Smokeless Tobacco Product Modified Risk Claims I: Consumer Product Demand

Smoking Behaviors
Roswell Park Cancer Institute160 enrolled1 locationNCT07102082
Recruiting
Phase 2

GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV

Cardiovascular Disease PreventionSmoking, CigaretteHIV+1 more
Vanderbilt University Medical Center200 enrolled1 locationNCT07221214
Recruiting

Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and Maintenance

Cigarette Smoking-Related Carcinoma
Roswell Park Cancer Institute40 enrolled1 locationNCT07439471
Recruiting
Not Applicable

A Novel Dialectical Behavior Therapy Brief Group Intervention for Cigarette Smoking by Patients With Cancer: An Open Clinical Trial

Smoking behavior
Wake Forest University Health Sciences16 enrolled2 locationsNCT07119489