Smoking Clinical Trials

89 recruiting

Smoking Trials at a Glance

214 actively recruiting trials for smoking are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 136 trials, with the heaviest enrollment activity in Buffalo, Charleston, and Houston. Lead sponsors running smoking studies include Medical University of South Carolina, University of California, San Francisco, and University of Oklahoma.

Treatments under study

About Smoking Clinical Trials

Looking for clinical trials for Smoking? There are currently 89 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Smoking trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Smoking clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 214 trials

Recruiting
Not Applicable

Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants

Smoking
Philip Morris Products S.A.108 enrolled1 locationNCT07443631
Recruiting
Not Applicable

Bladder Cancer Screening Trial

Urothelial CarcinomaBladder CancerSmoking Cessation+1 more
University of Texas Southwestern Medical Center1,000 enrolled1 locationNCT05646485
Recruiting
Phase 2

Dyadic Financial Incentive Treatments for Dual Smoker Couples

Smoking, Cigarette
University of Oklahoma900 enrolled2 locationsNCT06296849
Recruiting
Phase 4

Beta-Adrenergic Modulation of Drug Cue Reactivity

Tobacco Use DisorderNicotine DependenceCigarette Smoking
University of Oklahoma80 enrolled1 locationNCT05587361
Recruiting
Not Applicable

A Culturally Tailored Smartphone Application for African American Smokers

Smoking Cessation
University of Oklahoma30 enrolled1 locationNCT05188287
Recruiting
Not Applicable

Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking

Smoking Behaviors
Kaiser Permanente800 enrolled1 locationNCT07459621
Recruiting
Not Applicable

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

Cigarette SmokingTobacco ProductsElectronic Nicotine Delivery Systems
University of Chicago46 enrolled1 locationNCT06395415
Recruiting
Not Applicable

Digital Mindfulness Training Programme for Smoking Cessation and Maintenance

Smoking-related Disorder
Centre Hospitalier Universitaire Dijon40 enrolled1 locationNCT06500117
Recruiting
Early Phase 1

The Effect of Emotional Freedom Techniques (EFT) in Smokers Failing a Smoking Cessation Program

Smoking
Soul Medicine Institute40 enrolled1 locationNCT00981396
Recruiting
Not Applicable

Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT)

Smoking Cessation
Southcentral Foundation50 enrolled1 locationNCT06556238
Recruiting
Not Applicable

Smoke Free SafeCare: Establishing a Smoke Free Home in CPS-involved Families

Smoking BehaviorsChild Maltreatment
Georgia State University268 enrolled1 locationNCT05000632
Recruiting

Measuring Communal Coping in Dual-smoking Couples Making a Quit Attempt

Smoking (Tobacco) Addiction
University of Colorado, Denver250 enrolled1 locationNCT07553962
Recruiting
Not Applicable

Trauma-Informed Care for Smoking Cessation for Pregnancy

Smoking CessationSmoking, CigaretteTobacco Use Cessation+4 more
University of California, San Francisco20 enrolled1 locationNCT07129590
Recruiting
Not Applicable

Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia

SmokingSmoking CessationSmoking, Tobacco+2 more
University of Virginia768 enrolled1 locationNCT05660525
Recruiting
Phase 2

A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

Smoking
Eli Lilly and Company222 enrolled27 locationsNCT07223840
Recruiting
Not Applicable

Menthol, Inflammation, and Nicotine Transition Study

Inflammatory ResponseCigarette Smoking
Rosalind Franklin University of Medicine and Science68 enrolled1 locationNCT06232447
Recruiting
Not Applicable

Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)

Tobacco UseCigar Smoking
University of Oklahoma300 enrolled2 locationsNCT07162935
Recruiting
Not Applicable

Preliminary Effectiveness of Enhanced Text Message + Incentives

PregnancySmoking Cessation
University of Kansas Medical Center30 enrolled1 locationNCT07420621
Recruiting
Not Applicable

RTMS Targets Neural Circuits for Smoking Cessation

Tobacco UseCigarette Smoking
Medical University of South Carolina64 enrolled2 locationsNCT04903028
Recruiting
Phase 2

Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers

Cigarette Smoking-Related Carcinoma
National Cancer Institute (NCI)135 enrolled3 locationsNCT05121051