Defining the Basis of Fibromuscular Dysplasia (FMD)

Fibromuscular Dysplasia (FMD) is a non-inflammatory, non-atherosclerotic disease of blood vessel walls that primarily affects women and can cause arterial narrowing, dissection, or aneurysm, particularly in arteries supplying the kidneys and brain. This study aims to identify genetic causes and biological underpinnings of FMD and related conditions (SCAD and cervical artery dissection) by collecting blood samples and clinical information. You may be eligible if... - You are 18 years old or older (or a child with parental consent) - You have a confirmed clinical diagnosis of FMD, spontaneous coronary artery dissection (SCAD), or cervical artery dissection (CvAD) - OR you are an unaffected family member of a diagnosed patient - OR you are a healthy volunteer matched to a patient by age and gender - You speak English or Spanish You may NOT be eligible if... - Your life expectancy is less than 1 year - You have had an organ or bone marrow transplant - You have active autoimmune disease, HIV, illicit drug use, or prior malignancy - You have another form of vascular disease unrelated to FMD, SCAD, or CvAD - You have a family history of a different arteriopathy (e.g., Ehlers-Danlos syndrome) Talk to your doctor to see if this trial is right for you.