RecruitingNCT02387255

Magnetic Resonance Elastography in Patients With Abdominal Aortic Aneurysms

Sponsor

Ohio State University

Enrollment

165 participants

Start Date

Oct 1, 2014

Study Type

OBSERVATIONAL

Conditions

Abdominal Aortic Aneurysm

Summary

The main objective of this study is to utilize Magnetic Resonance Elastography (MRE) to determine tissue stiffness of abdominal aortic aneurysms (AAA). For patients with AAA, MRE is a more sensitive and superior method of determining the risk for rupture of AAA based on stiffness estimates when compared to the current, crude method of assessing risk based on measurement of the diameter of the aneurysm. The investigators will also validate the stiffness estimates against gold standard i.e. mechanical testing and histopathology only AAA patients undergoing AAA surgery.

Eligibility

Min Age: 20 Years

Inclusion Criteria2

Must be able to lie flat on their back in the scanner for up to 60 minutes
Must be able to hold breath for up to 15 seconds

Exclusion Criteria3

Patients who are claustrophobic
Patients who are pregnant
Patients with any unapproved, non-MRI save metal/devices in or on their body

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Interventions

DEVICEResoundant Driver System

This device is used to generate vibrations at the area of interest. The device has an active driver, a loud speaker sitting outside the scanner area, and a passive driver, which is shaped like a silicone paddle, which is secured with velcro straps to the area being imaged. Sound waves from the active driver travel through a tube attached to the passive driver and generate vibrations, images of which are captured by the MR scanner.