RecruitingNCT02496468

Pediatric Arm of DZL All Age Asthma Cohort

The All Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL), Pediatric Arm


Sponsor

LMU Klinikum

Enrollment

1,500 participants

Start Date

Jan 1, 2013

Study Type

OBSERVATIONAL

Conditions

Summary

Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).


Eligibility

Min Age: 6 MonthsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study follows children with asthma or recurrent wheezing to better understand how these breathing conditions develop and change over time in kids from infancy through age 18. **You may be eligible if...** - Your child is between 6 months and 18 years old - Your child was born at full term (at least 37 weeks) - Your child (ages 6 months to under 6 years) has had more than two episodes of wheezing in the past 12 months - Your child (age 6 or older) has been diagnosed with asthma by a doctor - You and your child understand German well enough to participate - Parents can provide informed consent; children over age 8 can also give their agreement **You may NOT be eligible if...** - Your child has a known lung condition present from birth (such as cystic fibrosis or primary ciliary dyskinesia) - Your child has had significant breathing problems related to heart disease - Your child required oxygen or mechanical breathing support after birth for more than 24 hours - Your child has a fever of 38.5°C or higher in the two weeks before the first visit - Your child has a non-allergic ongoing illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(5)

University Children's Hospital Cologne, Department of Paediatric Allergology and Pneumology

Cologne, Germany

Medizinische Hochschule Hannover, Biomedical Research in Endstage and Obstructive Lung Disease

Hanover, Germany

Universitaetsklinikum Schleswig-Holstein, Klinik für Kinder- und Jugendmedizin, Airway Research Center North

Lübeck, Germany

Klinik für Kinder- und Jugendmedizin, Universitaetsklinikum Giessen und Marburg GmbH, Universities of Giessen and Marburg Lung Center

Marburg, Germany

Klinikum der Universitaet Muenchen, Comprehensive Pulmonary Center Munich

Munich, Germany

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NCT02496468


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