RecruitingNCT02543996

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

Human Biospecimen Procurement and Analysis to Support Translational Research to Identify Genetic Etiology and Disease Mechanism(s) in Rare Genetic Vascular/Cardiovascular Diseases

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Enrollment

10,000 participants

Start Date

Sep 17, 2015

Study Type

OBSERVATIONAL

Conditions

Cardiovascular Disease Undiagnosed Diseases

Summary

Background: Studies show that rare genetic variants might lead to diseases. Researchers want to collect blood and tissue samples so they can study them and better understand diseases. Objective: To collect blood and tissue samples for studies to identify underlying causes of disease. Eligibility: People of all ages Design: Participants will have blood and/or tissue samples collected. Samples can be collected at the NIH Clinical Center. Participants doctors can collect the samples and send them to NIH. NIH staff can collect samples off site. For blood samples, blood is taken from an arm vein using a needle. Tissue collection may involve: Buccal smear: Cells are collected by scraping the inside of the cheek with a cotton swab. Saliva collection: Participants spit into a cup. Skin biopsy: A special needle takes a very small skin sample. Surgical waste tissue: If participants have surgery, NIH may receive samples of tissue that would routinely be removed. Umbilical cord or cord blood collection: If a participant has a baby, NIH may receive a small piece of the umbilical cord or blood from the cord once the baby is delivered.

Eligibility

Min Age: 1 MonthMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This NIH biorepository study collects blood, tissue, and other biological samples from patients with known or suspected diseases to support future research into disease mechanisms. Samples are stored and used for a wide range of translational studies. You may be eligible if: - You are more than 1 month old - You have a known or suspected medical condition being evaluated at NIH - You are a pregnant woman referred for evaluation of a known/suspected condition - You are a cognitively impaired individual with an affected condition or related to someone who is - You are willing to give informed consent You may NOT be eligible if: - You are a healthy volunteer unable to give informed consent - You are cognitively impaired but not affected by a relevant condition and not related to an affected person Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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