OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants With Elevated Lipoprotein(a)
Amgen
11,000 participants
Aug 22, 2025
INTERVENTIONAL
Conditions
Summary
The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).
Eligibility
Inclusion Criteria3
- Age ≥50 years
- Lp(a)≥ 200 nmol/L during screening
- Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis
Exclusion Criteria3
- Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia)
- Prior or planned arterial revascularization
- History of major bleeding disorder
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Interventions
Olpasiran will be administered via SC injection.
Placebo will be administered via SC injection.
Locations(238)
Advanced Cardiovascular LLC
Alexander City, Alabama, United States
University of Alabama Birmingham Saint Vincents Birmingham
Birmingham, Alabama, United States
Birmingham Clinical Research
Birmingham, Alabama, United States
Alliance For Multispecialty Research - Daphne
Daphne, Alabama, United States
Eastern Shore Research Institute
Fairhope, Alabama, United States
Heart Center Research LLC
Huntsville, Alabama, United States
CB Flock Research Corporation
Mobile, Alabama, United States
Phoenix Clinical
Phoenix, Arizona, United States
Elite Clinical Studies LLC
Phoenix, Arizona, United States
Hero Clinical Research
Phoenix, Arizona, United States
HonorHealth Research Institute
Scottsdale, Arizona, United States
Eclipse Clinical Research
Tucson, Arizona, United States
Lynn Institute of the Ozarks
Little Rock, Arkansas, United States
National Heart Institute
Beverly Hills, California, United States
310 Clinical Research
Inglewood, California, United States
University of California San Diego
La Jolla, California, United States
InvivoCure
Los Angeles, California, United States
Valley Clinical Trials
Northridge, California, United States
Clinical Trials Research - Sacramento
Roseville, California, United States
Alliance Clinical Research
San Diego, California, United States
Encompass Clinical Research
Spring Valley, California, United States
Stanford Health Care
Stanford, California, United States
Manshadi Heart Institute
Stockton, California, United States
Blue Coast Cardiology
Vista, California, United States
Diablo Clinical Research
Walnut Creek, California, United States
Focus Clinical Research
West Hills, California, United States
Interventional Cardiology Medical Group
West Hills, California, United States
UCHealth Memorial Central
Colorado Springs, Colorado, United States
South Denver Cardiology Associates
Littleton, Colorado, United States
Gandelman Cardiology, PC
Greenwich, Connecticut, United States
ClinTrial Hamden
Hamden, Connecticut, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
Excel Medical Clinical Trials
Boca Raton, Florida, United States
Clearwater Cardiovascular Consultants
Clearwater, Florida, United States
Proactive Clinical Research
Fort Lauderdale, Florida, United States
Indago Research and Health Center
Hialeah, Florida, United States
Elite Cardiac Research Center LLC
Hialeah, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
East Coast Institute for Research, LLC
Lake City, Florida, United States
Columbus Clinical Services LLC
Miami, Florida, United States
Kendall South Medical Center
Miami, Florida, United States
Inpatient Research Clinic, LLC
Miami Lakes, Florida, United States
Panax Clinical Research
Miami Lakes, Florida, United States
Eminat, LLC
Miramar, Florida, United States
Suncoast Clinical Research Inc
New Port Richey, Florida, United States
Ocala Cardiovascular Research
Ocala, Florida, United States
Ocala Research Institute, Inc
Ocala, Florida, United States
Ormond Beach Clinical Research
Ormond Beach, Florida, United States
Baptist Health Care
Pensacola, Florida, United States
Denali Health Plant City
Plant City, Florida, United States
FWD Clinical Research
Tamarac, Florida, United States
Guardian Research Organization LLC
Winter Park, Florida, United States
Emory University Hospital
Atlanta, Georgia, United States
East Coast Institute for Research
Canton, Georgia, United States
Northeast Georgia Medical Center Wisteria Building
Cumming, Georgia, United States
Nsc Research
Johns Creek, Georgia, United States
Georgia Clinical Research
Lawrenceville, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
St Lukes Idaho Cardiology Associates
Meridian, Idaho, United States
Solaris Clinical Research
Meridian, Idaho, United States
Endeavor Health-Northwest Community Healthcare
Arlington Heights, Illinois, United States
Christie Clinic
Champaign, Illinois, United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, United States
Alliance for Multispecialty Research, LLC - Park Ridge
Park Ridge, Illinois, United States
MediSphere Medical Research Center LLC
Evansville, Indiana, United States
Parkview Research Center
Fort Wayne, Indiana, United States
Franciscan Health Indianapolis
Indianapolis, Indiana, United States
Ascension Saint Vincent Heart Center
Indianapolis, Indiana, United States
Cardiovascular Research of Northwest Indiana LLC
Munster, Indiana, United States
Reid Physician Associates
Richmond, Indiana, United States
MercyOne Iowa Heart Center
West Des Moines, Iowa, United States
Hutchinson Clinic PA
Hutchinson, Kansas, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Midwest Heart and Vascular Specialists
Overland Park, Kansas, United States
Graves Gilbert Clinic
Bowling Green, Kentucky, United States
The Research Group of Lexington LLC
Lexington, Kentucky, United States
Heart Clinic of Hammond
Covington, Louisiana, United States
Ima Clinical Research
Monroe, Louisiana, United States
Louisiana Heart Center
Slidell, Louisiana, United States
Monroe Research LLC
West Monroe, Louisiana, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants LLC
Beltsville, Maryland, United States
Suburban Hospital
Bethesda, Maryland, United States
Flourish Research
Bowie, Maryland, United States
Johns Hopkins University
Columbia, Maryland, United States
Centennial Medical Group
Columbia, Maryland, United States
Medstar Franklin Square Medical Center
Hyattsville, Maryland, United States
Capitol Cardiology Associates
Lanham, Maryland, United States
Brigham and Womens Hospital
Boston, Massachusetts, United States
Henry Ford Health System
Detroit, Michigan, United States
Healthy Heart Cardiology
Grand Rapids, Michigan, United States
MyMichigan Medical Center Midland - Clinical Research Department
Midland, Michigan, United States
Advanced Cardiology Associates
Rochester Hills, Michigan, United States
Revival Research Institute
Southfield, Michigan, United States
Health East Cancer Care
Maplewood, Minnesota, United States
University of Minnesota
Minneapolis, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Methodist Hospital
Saint Louis Park, Minnesota, United States
Jackson Heart Clinic
Jackson, Mississippi, United States
Cardiology Associates Research LLC
Tupelo, Mississippi, United States
Sisters of Saint Mary Health Heart and Vascular Care
Bridgeton, Missouri, United States
Kansas City Veterans Affairs Medical Center
Kansas City, Missouri, United States
Washington University
St Louis, Missouri, United States
Bryan Heart
Lincoln, Nebraska, United States
Excel Clinical Research
Las Vegas, Nevada, United States
American Institute of Medical Research
Las Vegas, Nevada, United States
Las Vegas Clinical Trials
North Las Vegas, Nevada, United States
Renown Institute for Heart and Vascular Health
Reno, Nevada, United States
Advanced Heart and Vascular Institute of Hunterdon
Flemington, New Jersey, United States
Clinical Reseach Philadelphia Pennington
Hamilton, New Jersey, United States
Med Clinical Research Partners - Irvington
Irvington, New Jersey, United States
New Jersey Medcare / New Jersey Heart
Linden, New Jersey, United States
Saint Michaels Medical Center
Newark, New Jersey, United States
Circuit Clinical / Optum Medical Care of New Jersey
Secaucus, New Jersey, United States
The Heart House - Washington Township
Sewell, New Jersey, United States
CardioMetabolic Collaborative Clinic
Somerset, New Jersey, United States
Ima Clinical Research - Warren
Warren Township, New Jersey, United States
Albany Medical College
Albany, New York, United States
Basil Clinical
Inwood, New York, United States
Rasai Research
Jackson Heights, New York, United States
Crystal Run Healthcare
Monroe, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Mount Sinai Queens
New York, New York, United States
Ima Clinical Research Manhattan
New York, New York, United States
Niagara Falls Memorial Medical Center
Niagara Falls, New York, United States
Circuit Clinical Orchard Park Family Practice
Orchard Park, New York, United States
Hudson Valley Cardiovascular Physicians PC
Poughkeepsie, New York, United States
Saratoga Clinical Research, LLC
Saratoga Springs, New York, United States
Moses H Cone Memorial Hospital
Greensboro, North Carolina, United States
Medication Management LLC
Greensboro, North Carolina, United States
Triad Clinical Trials, LLC
Greensboro, North Carolina, United States
ClinCept, LLC
Kinston, North Carolina, United States
Monroe Biomedical Research
Monroe, North Carolina, United States
Piedmont Healthcare
Statesville, North Carolina, United States
Accellacare Research of Wilmington
Wilmington, North Carolina, United States
Aultman Cardiology Clinical Trials
Canton, Ohio, United States
The Christ Hospital
Cincinnati, Ohio, United States
Velocity Clinical Research - Cincinnati
Cincinnati, Ohio, United States
Nexgen Research
Lima, Ohio, United States
K and R Research
Marion, Ohio, United States
Alliance for Multispecialty Research
Norman, Oklahoma, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Preferred Primary Care Physicians, Inc
Pittsburgh, Pennsylvania, United States
Pottstown Medical Specialists Inc
Pottstown, Pennsylvania, United States
Pharmacorp Clinical Trials Inc
Charleston, South Carolina, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Prisma Health Carolina Cardiology - Greenville
Gantt, South Carolina, United States
Walker Family Care
Little River, South Carolina, United States
Accellacare Charleston
Mt. Pleasant, South Carolina, United States
Tribe Clinical Research - Spartanburg
Spartanburg, South Carolina, United States
Monument Health Clinical Research
Rapid City, South Dakota, United States
Erlanger Health, Inc.
Chattanooga, Tennessee, United States
Apex Research Foundation, LLC
Jackson, Tennessee, United States
Alliance for Multispecialty Research Knoxville
Knoxville, Tennessee, United States
Ascension Saint Thomas
Nashville, Tennessee, United States
Parkway Cardiology Associates
Oak Ridge, Tennessee, United States
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, United States
PharmaTex Research, LLC
Amarillo, Texas, United States
Texas Diabetes and Endocrinology
Austin, Texas, United States
Ima Clinical Research
Austin, Texas, United States
Pioneer Medical Associates
Carrollton, Texas, United States
Baylor Scott and White Heart and Vascular Hospital-Dallas
Dallas, Texas, United States
Zenos Clinical Research
Dallas, Texas, United States
The Heartbeat Clinic
Dallas, Texas, United States
Cedar Health Research, LLC
Dallas, Texas, United States
Cedar Health Research, LLC
Euless, Texas, United States
East Texas Cardiology PA
Houston, Texas, United States
Baylor College of Medicine
Houston, Texas, United States
Cardiovascular Specialists of Willowbrook
Houston, Texas, United States
Vital Heart and Vein
Humble, Texas, United States
Tcr Institute Llc
Kingwood, Texas, United States
Epic Clinical Research
Lewisville, Texas, United States
Texas Tech University Health Sciences Center
Lubbock, Texas, United States
North Dallas Research Associates
McKinney, Texas, United States
Revival Research Institute
McKinney, Texas, United States
Texas Institute of Cardiology
McKinney, Texas, United States
Southern Endocrinology Associates PA
Mesquite, Texas, United States
Orion Medical
Pasadena, Texas, United States
Valley Institute of Research Plano
Plano, Texas, United States
Ima Clinical Research San Antonio
San Antonio, Texas, United States
St Davids Heart & Vascular PLLC dba Austin Heart
San Marcos, Texas, United States
Tyler Cardiovascular Consultants
Tyler, Texas, United States
Alpine Research Organization
Layton, Utah, United States
Inova Cardiology - Fairfax
Fairfax, Virginia, United States
Virginia Heart
Falls Church, Virginia, United States
Virginia Heart - Loudoun
Leesburg, Virginia, United States
Carient Heart and Vascular
Manassas, Virginia, United States
Bon Secours Cardiology
Midlothian, Virginia, United States
Tidewater Physicians Multispecialty Group Clinical Research
Newport News, Virginia, United States
Alliance for Multispecialty Research Norfolk
Norfolk, Virginia, United States
Centricity Research
Suffolk, Virginia, United States
Selma Medical Associates
Winchester, Virginia, United States
Winchester Medical Center
Winchester, Virginia, United States
Western Washington Medical Group
Everett, Washington, United States
Rainier Clinical Research Center
Renton, Washington, United States
Canberra Hospital
Garran, Australian Capital Territory, Australia
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia
Novatrials
Charlestown, New South Wales, Australia
Concord Repatriation General Hospital
Concord, New South Wales, Australia
Aim Research
Merewether, New South Wales, Australia
Orange Health Service
Orange, New South Wales, Australia
Wollongong Hospital
Wollongong, New South Wales, Australia
Advara HeartCare Wesley
Auchenflower, Queensland, Australia
Core Research Group Pty Ltd
Milton, Queensland, Australia
University of The Sunshine Coast Clinical Trials, Sippy Downs
Sippy Downs, Queensland, Australia
Dr Heart Pty Ltd
Woolloongabba, Queensland, Australia
Flinders Medical Centre
Bedford Park, South Australia, Australia
Advara HeartCare Leabrook
Leabrook, South Australia, Australia
Fusion Clinical Research
Norwood, South Australia, Australia
Victorian Heart Hospital
Clayton, Victoria, Australia
The Alfred Hospital
Melbourne, Victoria, Australia
Momentum Clinical Research - Sunshine
Melbourne, Victoria, Australia
Clinitrials - Mandurah
Greenfields, Western Australia, Australia
Advara HeartCare Joondalup
Joondalup, Western Australia, Australia
Hollywood Private Hospital
Nedlands, Western Australia, Australia
Linear Clinical Research Limited
Nedlands, Western Australia, Australia
Clinitrials - Mount Medical Centre
Perth, Western Australia, Australia
Centricity Research Calgary
Calgary, Alberta, Canada
Edmonton Cardiology Consultants
Edmonton, Alberta, Canada
Fraser Clinical Trials
New Westminster, British Columbia, Canada
SMH Cardiology Clinical Trials Incorporated
Surrey, British Columbia, Canada
ARC Biosystems Incorporated
Vancouver, British Columbia, Canada
Victoria Heart Institute Foundation
Victoria, British Columbia, Canada
Discovery Clinical Services Ltd
Victoria, British Columbia, Canada
Centricity Research Brampton
Brampton, Ontario, Canada
Premier Clinical Trial Network
Hamilton, Ontario, Canada
Elevate Clinical Research KMH Missisauga
Mississauga, Ontario, Canada
Partners in Advanced Cardiac Evaluation
Newmarket, Ontario, Canada
North York Diagnostic and Cardiac Centre
North York, Ontario, Canada
Oakville Cardiovascular Research
Oakville, Ontario, Canada
Heart Health Institute Research Incorporated
Scarborough Village, Ontario, Canada
Ecogene-21
Chicoutimi, Quebec, Canada
Montreal Heart Institute
Montreal, Quebec, Canada
Institut de recherches cliniques de Montreal
Montreal, Quebec, Canada
Centre de Recherche du Centre Hospitalier de l Universite de Montreal
Montreal, Quebec, Canada
Research Institute of McGill University Health Center - Glen Site
Montreal, Quebec, Canada
CIUSSS de l Estrie CHUS Hopital Fleurimont
Sherbrooke, Quebec, Canada
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07136012