Neonatal Neurologic Intensive Care Network of China
Children's Hospital of Fudan University
2,000 participants
Sep 1, 2015
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to create a neonatal neurologic biological big data center named Neonatal Neurologic Intensive Care Network in China with neonatal systematic information, biological samples and genomics \& genetic data on neonates born with neonatal severe encephalopathy. It also can predict brain injury as cerebral function monitoring through big data and recommend appropriate treatment. In addition, the following samples will be collected in a bio-bank in for future studies: blood, urine, and cerebrospinal fluid (CSF) samples.
Eligibility
Inclusion Criteria16
- Postnatal age \< or = 28 days
- Written informed consent of parent or guardian
- With one of the following items
- Hypoxic ischemic encephalopathy (HIE)
- Hydrocephalus
- Hypotonia
- Interventricular hemorrhages
- Intracranial calcifications
- Intracranial hemorrhages
- Meningitis and other brain infections
- Metabolic diseases
- Microcephaly
- Neonatal stroke
- Spina bifid
- Cerebral arteriovenous malformations (AVMs)
- Congenital brain malformations
Exclusion Criteria3
- Known other major congenital anomalies but not not neurologic disease.
- Failed to get sample or the volume of collected biosamples is not enough.
- Parents refuse consent.
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Interventions
blood, urine, CFS samples and medical data collected
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT02544100