RecruitingPhase 1NCT02646475

Metabolic Effects of Angiotensin-(1-7)

Sponsor

Vanderbilt University

Enrollment

26 participants

Start Date

Feb 1, 2016

Study Type

INTERVENTIONAL

Conditions

Obesity Insulin Resistance Hypertension Metabolic Cardiovascular Syndrome

Summary

The overall purpose of this study is to learn more about the metabolic effects of angiotensin-(1-7) in the insulin resistant state associated with obesity. Pharmacologic approaches to increase angiotensin-(1-7) levels or its actions are currently in development for treatment of metabolic-related diseases such as obesity and type II diabetes, based on findings from animal studies. It is unclear if this peptide contributes to the regulation of metabolism in humans. The investigators will test if angiotensin-(1-7) infusion can improve insulin sensitivity measured by hyperinsulinemic-euglycemic clamp methods in individuals with obesity and insulin resistance. The investigators will also examine for changes in blood pressure and related hemodynamic and hormonal changes following angiotensin-(1-7) infusion.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how a naturally occurring substance in the body called angiotensin-(1-7) affects metabolism — including blood sugar control and blood vessel function — which may have implications for treating conditions like diabetes and high blood pressure. **You may be eligible if...** - You are an adult between the ages specified in the study protocol - You may have conditions like overweight, pre-diabetes, or metabolic syndrome (a cluster of conditions including high blood sugar, excess belly fat, and abnormal cholesterol) - You are not currently on medications that would interfere with the study **You may NOT be eligible if...** - You have serious kidney or liver disease - You have uncontrolled diabetes or blood pressure - You are taking certain blood pressure medications (ACE inhibitors or ARBs) that would interfere with the study - You are pregnant or breastfeeding - You have a history of certain heart conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGAngiotensin-(1-7)

This is a biologically active endogenous angiotensin peptide. It may play an important role in the regulation of blood pressure by dilating blood vessels as well as a role in the regulation of insulin action.

DRUGSaline

Normal saline will be used as a placebo comparator.