Insulin Resistance Clinical Trials

98 recruitingLast updated: June 17, 2026

There are 98 actively recruiting insulin resistance clinical trials across 27 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 3. Top locations include New York, New York, United States, Tübingen, Germany, Ann Arbor, Michigan, United States. Updated daily from ClinicalTrials.gov.


Insulin Resistance Trials at a Glance

98 actively recruiting trials for insulin resistance are listed on ClinicalTrialsFinder across 6 cities in 27 countries. The largest study group is Not Applicable with 61 trials, with the heaviest enrollment activity in New York, Tübingen, and Ann Arbor. Lead sponsors running insulin resistance studies include Columbia University, University Hospital Tuebingen, and University of Michigan.

Browse insulin resistance trials by phase

Treatments under study

About Insulin Resistance Clinical Trials

Looking for clinical trials for Insulin Resistance? There are currently 86 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Insulin Resistance trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Insulin Resistance clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 98 trials

Recruiting

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

CancerInsulin ResistanceMetabolic Syndrome+2 more
National Institute of Environmental Health Sciences (NIEHS)725 enrolled1 locationNCT01143480
Recruiting

Genetic Studies of Insulin and Diabetes

Diabetes MellitusSevere Insulin Resistance
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1,200 enrolled1 locationNCT00001987
Recruiting
Not Applicable

Exercise Effects on Adipose Tissue Structure and Function

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan46 enrolled1 locationNCT04812314
Recruiting

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

ObesityInsulin ResistanceMetabolic Disease+2 more
University of Michigan175 enrolled1 locationNCT06007404
Recruiting
Not Applicable

The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV

Insulin ResistanceDepression in AdultsHIV+1 more
Indiana University150 enrolled1 locationNCT07226128
Recruiting
Phase 1

Graded Insulin Suppression Test P&F

ObesityInsulin ResistanceHealthy+1 more
Columbia University15 enrolled1 locationNCT06592261
Recruiting
Not Applicable

Personalized Meal Timing and Walking Based on Glucose Patterns in Adults With Prediabetes

PrediabetesPrediabetes (Insulin Resistance, Impaired Glucose Tolerance)Prediabetes or Diabetes
Shifa International Hospital105 enrolled1 locationNCT07618663
Recruiting
Phase 1

Metabolic Effects of Angiotensin-(1-7)

ObesityInsulin ResistanceHypertension+1 more
Vanderbilt University26 enrolled1 locationNCT02646475
Recruiting
Not Applicable

PREdiabetes GLycemic Impact and Data Evaluation

Insulin ResistanceObesity, OverweightPre-diabetic
Nazarii Kobyliak80 enrolled2 locationsNCT07599072
Recruiting
Not Applicable

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

ObesityInsulin ResistanceMuscle Weakness+2 more
University of Colorado, Denver70 enrolled1 locationNCT06129110
Recruiting

Collection of Human Metabolic Tissues

ObesityInsulin ResistanceDiabetes Mellitus, Type 2
University Hospital, Montpellier270 enrolled1 locationNCT02861781
Recruiting
Phase 2

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

Insulin ResistanceChronic Kidney DiseasesFatigue+4 more
University of California, Davis80 enrolled2 locationsNCT04984226
Recruiting
Not Applicable

Artichoke By-products Rich in Hydroxycinnamic Acids and Mediterranean Diet for Type 2 Diabetes Prevention.

Obesity, OverweightDiabete Type 2Insulin Resistance Syndrome
Clinica Universidad de Navarra, Universidad de Navarra150 enrolled1 locationNCT07415720
Recruiting

Cardiometabolic Disease and Substrate Metabolism

Insulin ResistancePregnancyPregnancy Complications+9 more
University of Tennessee Graduate School of Medicine50 enrolled1 locationNCT07565727
Recruiting

Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

ObesityInsulin ResistanceHyperinsulinism+2 more
Ali Chappell150 enrolled1 locationNCT05950282
Recruiting
Not Applicable

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Insulin ResistanceHyperinsulinismDepression+5 more
Colorado State University300 enrolled2 locationsNCT05543083
Recruiting
Not Applicable

Metabolic Adaptations to Weight Loss With and Without Exercise

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan68 enrolled1 locationNCT05806801
Recruiting
Phase 1

Effect of Insulin Lowering on Lipogenesis

ObesityInsulin ResistanceNon-Alcoholic Fatty Liver Disease+2 more
Columbia University25 enrolled1 locationNCT07403604
Recruiting
Phase 1

Human Models of Selective Insulin Resistance: Alpelisib, Part I

Insulin ResistanceNon-Alcoholic Fatty Liver DiseaseOverweight and Obesity+1 more
Columbia University32 enrolled1 locationNCT06354088
Recruiting
Not Applicable

Electro-Acupuncture for Obese Patients With Insulin Resistance

ObesityInsulin Resistance
Nanyang Technological University60 enrolled1 locationNCT06609200