Insulin Resistance Clinical Trials

78 recruiting

Insulin Resistance Trials at a Glance

87 actively recruiting trials for insulin resistance are listed on ClinicalTrialsFinder across 6 cities in 22 countries. The largest study group is Not Applicable with 52 trials, with the heaviest enrollment activity in New York, Tübingen, and Ann Arbor. Lead sponsors running insulin resistance studies include Columbia University, University Hospital Tuebingen, and University of Michigan.

Browse insulin resistance trials by phase

Treatments under study

About Insulin Resistance Clinical Trials

Looking for clinical trials for Insulin Resistance? There are currently 78 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Insulin Resistance trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Insulin Resistance clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 87 trials

Recruiting

Genetic Studies of Insulin and Diabetes

Diabetes MellitusSevere Insulin Resistance
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1,200 enrolled1 locationNCT00001987
Recruiting
Not Applicable

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

ObesityInsulin ResistanceMuscle Weakness+2 more
University of Colorado, Denver70 enrolled1 locationNCT06129110
Recruiting

Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

ObesityInsulin ResistanceHyperinsulinism+2 more
Ali Chappell150 enrolled1 locationNCT05950282
Recruiting
Not Applicable

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Insulin ResistanceHyperinsulinismDepression+5 more
Colorado State University300 enrolled2 locationsNCT05543083
Recruiting
Not Applicable

The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV

Insulin ResistanceDepression in AdultsHIV+1 more
Indiana University150 enrolled1 locationNCT07226128
Recruiting

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

CancerInsulin ResistanceMetabolic Syndrome+2 more
National Institute of Environmental Health Sciences (NIEHS)725 enrolled1 locationNCT01143480
Recruiting
Not Applicable

Metabolic Adaptations to Weight Loss With and Without Exercise

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan68 enrolled1 locationNCT05806801
Recruiting
Phase 1

Human Models of Selective Insulin Resistance: Alpelisib, Part I

Insulin ResistanceNon-Alcoholic Fatty Liver DiseaseOverweight and Obesity+1 more
Columbia University32 enrolled1 locationNCT06354088
Recruiting
Not Applicable

Electro-Acupuncture for Obese Patients With Insulin Resistance

ObesityInsulin Resistance
Nanyang Technological University60 enrolled1 locationNCT06609200
Recruiting
Phase 1

Effect of Insulin Lowering on Lipogenesis

ObesityInsulin ResistanceNon-Alcoholic Fatty Liver Disease+2 more
Columbia University25 enrolled1 locationNCT07403604
Recruiting
Not Applicable

Effects of Antipsychotics on Brain Insulin Action in Females

Insulin ResistanceMenstrual CycleType 2 Diabetes+1 more
Centre for Addiction and Mental Health15 enrolled1 locationNCT06251635
Recruiting
Phase 2

MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity

Insulin ResistancePrediabetesOverweight/Obesity
Hudson Biotech120 enrolled1 locationNCT07505745
Recruiting
Phase 2

Efficacy and Safety of Oral Controlled-release Nicotinic Acid (CIR-NA) for the Remission of Prediabetes. (CONCEPT)

Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
University Hospital Schleswig-Holstein390 enrolled2 locationsNCT07286747
Recruiting
Not Applicable

Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation

Cognitive DysfunctionPrediabetes (Insulin Resistance, Impaired Glucose Tolerance)Overweight (BMI > 25)+3 more
Leeds Beckett University70 enrolled1 locationNCT07073781
Recruiting
Not Applicable

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

Arterial StiffnessBody CompositionAdult+9 more
Georgia State University30 enrolled1 locationNCT06735651
Recruiting
Not Applicable

Peanuts for Cardiometabolic, Brain, and Intestinal Health

AdultPrediabetesCognition+5 more
Georgia State University72 enrolled1 locationNCT06867198
Recruiting
Not Applicable

ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence

Insulin ResistancePhysical ActivityPCOS (Polycystic Ovary Syndrome)+1 more
Massachusetts General Hospital40 enrolled1 locationNCT07102797
Recruiting
Not Applicable

Glucose Profiles in Women With Polycystic Ovary Syndrome

Insulin ResistancePolycystic Ovary SyndromeGlucose Profile+1 more
Centre Hospitalier Universitaire, Amiens80 enrolled1 locationNCT07483723
Recruiting
Not Applicable

Effects of Cranberry on Gut and Metabolic Health

Insulin ResistanceMetabolic SyndromeMicrobiota+1 more
Laval University73 enrolled1 locationNCT07460856
Recruiting

Mitochondrial Substrate Utilization in the Diabetic Human Heart

Heart FailureInsulin ResistanceMitochondrial Diseases+2 more
Heinrich-Heine University, Duesseldorf500 enrolled1 locationNCT05958706