RecruitingNCT02673996

POTS Adrenergic Ab (CIHR Aims #1&2)

The Pathophysiological Role of Adrenergic Antibodies in Postural Tachycardia Syndrome (Aims #1&2)


Sponsor

University of Calgary

Enrollment

125 participants

Start Date

Jan 1, 2016

Study Type

OBSERVATIONAL

Conditions

Summary

Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Isoproterenol and a drug called Phenylephrine for people with postural tachycardia syndrome. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 60 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPhenylephrine

incremental small doses of IV phenylephrine to find the dose that transiently raises systolic blood pressure by 25 mmHg

DRUGIsoproterenol

incremental small doses of IV isoproterenol to find the dose that transiently raises heart rate by 25 bpm


Locations(1)

University of Calgary

Calgary, Alberta, Canada

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NCT02673996


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