RecruitingNot ApplicableNCT05043051

Autoimmune Basis for Postural Tachycardia Syndrome

Sponsor

University of Oklahoma

Enrollment

80 participants

Start Date

Jan 14, 2022

Study Type

INTERVENTIONAL

Conditions

Postural Tachycardia Syndrome

Summary

The purpose of this study is to test the hypothesis that an antibody-mediated autoimmune reaction will cause symptoms of autonomic dysfunction in some patients with postural tachycardia syndrome (POTS). The investigators further hypothesize that electrical stimulation of the vagus nerve will improve POTS symptoms, autoimmunity and inflammation.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria4

-80 years old, female or male
Either healthy control or individual with postural tachycardia syndrome (POTS) defined as heart rate increase >30 bpm from supine within 10 min of standing, in the absence of orthostatic hypotension (>20/10 mmHg fall in blood pressure), with chronic symptoms (>6 months), and in the absence of other acute cause of orthostatic tachycardia
Able and willing to provide informed consent
Understand and be able to comply with the study procedures and restrictions

Exclusion Criteria9

Hypertension (>150 mmHg systolic and >100 mmHg diastolic) based on history or findings at screening
Orthostatic hypotension (consistent drop in blood pressure >20/10 mmHg with 10 min of standing)
Cardiovascular disease, such as myocardial infarction within 6 months
History or presence of significant immunological or hematological disorders
History of vagotomy
Currently pregnant women or women planning on becoming pregnant ≤ 3 months
Inability to comply with the protocol
Patients with active implants (such as a cardiac pacemaker, or a cochlear implant)
Healthy control subjects will be healthy, non-smoking and on no chronic medications at the time of the study. Healthy control subjects will be group-matched to the POTS patients for age and gender.