Postural Tachycardia Syndrome Clinical Trials

11 recruitingLast updated: May 29, 2026

There are 11 actively recruiting postural tachycardia syndrome clinical trials across 4 countries. Studies span Not Applicable, Phase 2. Top locations include Nashville, Tennessee, United States, Calgary, Alberta, Canada, Brussels, Belgium. Updated daily from ClinicalTrials.gov.


Postural Tachycardia Syndrome Trials at a Glance

11 actively recruiting trials for postural tachycardia syndrome are listed on ClinicalTrialsFinder across 6 cities in 4 countries. The largest study group is Not Applicable with 4 trials, with the heaviest enrollment activity in Nashville, Calgary, and Brussels. Lead sponsors running postural tachycardia syndrome studies include University of Calgary, Vanderbilt University Medical Center, and RWTH Aachen University.

Browse postural tachycardia syndrome trials by phase

Treatments under study

About Postural Tachycardia Syndrome Clinical Trials

Looking for clinical trials for Postural Tachycardia Syndrome? There are currently 8 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Postural Tachycardia Syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Postural Tachycardia Syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 111 of 11 trials

Recruiting
Not Applicable

Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome

Orthostatic intolerancePostural Tachycardia Syndrome
University of Calgary26 enrolled1 locationNCT04271878
Recruiting

POTS Adrenergic Ab (CIHR Aims #1&2)

Postural Tachycardia Syndrome
University of Calgary125 enrolled1 locationNCT02673996
Recruiting
Not Applicable

Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?

Postural Tachycardia Syndrome
Virginia Commonwealth University36 enrolled1 locationNCT05618054
Recruiting
Phase 2

A Study of Pyridostigmine in Postural Tachycardia Syndrome

Postural Tachycardia Syndrome
Mayo Clinic50 enrolled1 locationNCT00409435
Recruiting
Phase 2

Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS

SARS-CoV-2 infectionPost-Acute COVID-19 SyndromeLong Covid19+1 more
Vanderbilt University Medical Center50 enrolled1 locationNCT07189936
Recruiting
Not Applicable

Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome

SARS-CoV-2 infectionPost-Acute COVID-19 SyndromeLong COVID+1 more
Vanderbilt University Medical Center60 enrolled1 locationNCT05421208
Recruiting
Phase 2

Splanchnic Venous Capacitance in Postural Tachycardia Syndrome

Postural Tachycardia Syndrome (POTS)
Vanderbilt University Medical Center50 enrolled1 locationNCT05375968
Recruiting

Inappropriate Sinus Tachycardia Registry

Postural Tachycardia SyndromeInappropriate Sinus Tachycardia
AtriCure, Inc.500 enrolled10 locationsNCT05107635
Recruiting
Not Applicable

Autoimmune Basis for Postural Tachycardia Syndrome

Postural Tachycardia Syndrome
University of Oklahoma80 enrolled1 locationNCT05043051
Recruiting

Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry

Small Fiber NeuropathyPostural Tachycardia SyndromeAutonomic Neuropathy+1 more
RWTH Aachen University200 enrolled1 locationNCT04310644
Recruiting
Phase 2

Crossover Study of Propranolol vs Ivabradine in POTS

Postural Tachycardia Syndrome
University of Calgary20 enrolled1 locationNCT04186286