RecruitingPhase 2NCT02727803

Personalized NK Cell Therapy in CBT


Sponsor

M.D. Anderson Cancer Center

Enrollment

100 participants

Start Date

May 19, 2016

Study Type

INTERVENTIONAL

Conditions

Summary

This phase II clinical trial studies how well personalized natural killer (NK) cell therapy works after chemotherapy and umbilical cord blood transplant in treating patients with myelodysplastic syndrome, leukemia, lymphoma or multiple myeloma. This clinical trial will test cord blood (CB) selection for human leukocyte antigen (HLA)-C1/x recipients based on HLA-killer-cell immunoglobulin-like receptor (KIR) typing, and adoptive therapy with CB-derived NK cells for HLA-C2/C2 patients. Natural killer cells may kill tumor cells that remain in the body after chemotherapy treatment and lessen the risk of graft versus host disease after cord blood transplant.


Eligibility

Min Age: 15 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a personalized natural killer (NK) cell therapy — using immune cells from a cord blood transplant donor — can help patients with blood cancers recover better after a cord blood stem cell transplant. **You may be eligible if...** - You have a blood cancer such as acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic myelogenous leukemia (CML), or certain types of lymphoma - Your cancer has not responded to standard treatment, has returned after treatment, or you are considered high risk for relapse - You are scheduled to receive a cord blood stem cell transplant - You are in adequate overall health to tolerate the transplant **You may NOT be eligible if...** - Your heart, liver, kidneys, or lungs are not functioning well enough - You have an active, uncontrolled infection - You are pregnant or breastfeeding - You have other serious medical conditions that make a transplant too risky Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALAllogeneic Natural Killer Cell Line NK-92

Given IV

BIOLOGICALAnti-Thymocyte Globulin

Given IV

DRUGBusulfan

Given IV

DRUGClofarabine

Given IV

DRUGCyclophosphamide

Given IV

DRUGFludarabine Phosphate

Given IV

OTHERLaboratory Biomarker Analysis

Correlative studies

DRUGMelphalan

Given IV

BIOLOGICALRituximab

Given IV

RADIATIONTotal-Body Irradiation

Undergo total body irradiation

PROCEDUREUmbilical Cord Blood Transplantation

Undergo umbilical cord blood transplantation


Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT02727803


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