RecruitingNCT02780297

Prospective Research Rare Kidney Stones (ProRKS)


Sponsor

Mayo Clinic

Enrollment

220 participants

Start Date

May 1, 2016

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study, called ProRKS (Prospective Research Rare Kidney Stones), collects information from patients with rare kidney stone conditions to better understand how these diseases develop and progress over time. You may be eligible if: - You have been diagnosed with primary hyperoxaluria - You have been diagnosed with enteric hyperoxaluria - You have been diagnosed with Dent Disease (including if you are a carrier) - You have been diagnosed with Cystinuria - You have been diagnosed with adenine phosphoribosyltransferase deficiency (APRTd) - You have been diagnosed with Lowe Syndrome You may NOT be eligible if: - You have previously experienced kidney (renal) failure - You have a history of liver and/or kidney transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(11)

University of Alabama @ Birmingham

Birmingham, Alabama, United States

Mayo Clinic Jacksonville

Jacksonville, Florida, United States

Children's Memorial Hospital

Chicago, Illinois, United States

Children's Hospital, Harvard Medical School

Boston, Massachusetts, United States

Mayo Clinic Hyperoxaluria Center

Rochester, Minnesota, United States

New York University

New York, New York, United States

Cincinnati Children's Hosptial Medical Center

Cincinnati, Ohio, United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Hosptial of Sick Children

Toronto, Ontario, Canada

Landspitali Universtiy Hospital

Reykjavik, Iceland

Shaare Zedek Medica Center

Jerusalem, Israel

View Full Details on ClinicalTrials.gov

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NCT02780297


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