Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia

This study uses innovative near-infrared spectroscopy (NIRS) brain monitoring technology in newborns who have experienced birth-related brain injury (hypoxic-ischemic encephalopathy or HIE). Researchers want to see if this new monitoring approach can help optimize cooling therapy (therapeutic hypothermia), which is used to protect the brain after birth injury. You may be eligible if: - Your newborn was born at more than 33 weeks gestational age - Your newborn is either: (1) receiving therapeutic hypothermia (cooling treatment) as clinical management, OR (2) showing signs of neurological problems such as seizures, altered consciousness, breathing difficulties, feeding problems, abnormal tone, or abnormal reflexes - Parents are willing to consent to monitoring in the first week of life You may NOT be eligible if: - Your newborn was born at 33 weeks or earlier (premature) - Your newborn weighs less than 2.0 kg at birth - Your newborn has an implanted device or other condition that prevents MRI scanning Talk to your doctor to see if this trial is right for you.