The Role of Cardiac Mechanics, Biomarkers and Frailty in Aortic Stenosis

This study is investigating how the mechanics of the heart, specific blood protein markers, and physical frailty relate to outcomes in patients with aortic stenosis — a narrowing of the main heart valve that makes it harder for the heart to pump blood — as well as in patients with heart failure where pumping function is preserved. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with moderate aortic stenosis, severe aortic stenosis, or heart failure with preserved pumping function - Or you are a healthy volunteer willing to serve as a control participant **You may NOT be eligible if...** - You have already had your aortic valve replaced or repaired by surgery or a catheter-based procedure - You have severe mitral valve disease or a significantly leaking aortic valve - You have other significant heart conditions that could affect the study results Talk to your doctor to see if this trial is right for you.