Aortic Stenosis Clinical Trials

106 recruitingLast updated: July 10, 2026

There are 106 actively recruiting aortic stenosis clinical trials across 44 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1, Phase 1. Top locations include Boston, Massachusetts, United States, New York, New York, United States, Minneapolis, Minnesota, United States. Updated daily from ClinicalTrials.gov.


Aortic Stenosis Trials at a Glance

106 actively recruiting trials for aortic stenosis are listed on ClinicalTrialsFinder across 6 cities in 44 countries. The largest study group is Not Applicable with 48 trials, with the heaviest enrollment activity in Boston, New York, and Minneapolis. Lead sponsors running aortic stenosis studies include Second Affiliated Hospital, School of Medicine, Zhejiang University, China National Center for Cardiovascular Diseases, and Abbott Medical Devices.

Browse aortic stenosis trials by phase

Treatments under study

About Aortic Stenosis Clinical Trials

Looking for clinical trials for Aortic Stenosis? There are currently 69 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Aortic Stenosis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Aortic Stenosis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 106 trials

Recruiting
Not Applicable

A Clinical Trial Assessing the Safety and Effectiveness of the DurAVR® THV System

Severe aortic stenosisValve-in-valve Procedures
Anteris Technologies Ltd.1,650 enrolled13 locationsNCT07194265
Recruiting
Not Applicable

ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve

Aortic Stenosis, Severe
Edwards Lifesciences1,234 enrolled65 locationsNCT05172960
Recruiting

PERFECT - Portuguese Evolut Registry Studying the Outcomes of Medtronic Evolut™ FX+ TAVI System by Evaluating an Optimal Care Pathway for TAVI

Severe Symptomatic Aortic Stenosis (Defined as New York Heart Association (NYHA) Class ≥ II)
Portuguese Association of Interventional Cardiology500 enrolled12 locationsNCT07343674
Recruiting
Not Applicable

Aspirin vs Clopidogrel After TAVR

Severe aortic stenosis
Yonsei University270 enrolled1 locationNCT05493657
Recruiting

Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS Study

GeneticsPathogenesisAortic Stenosis+3 more
Heinrich-Heine University, Duesseldorf938 enrolled3 locationsNCT05851209
Recruiting
Not Applicable

CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

Aortic Valve DiseaseAortic StenosisAortic Valve Stenosis
EmStop Inc663 enrolled3 locationsNCT07276711
Recruiting
Phase 2

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

Aortic Stenosis
Novartis Pharmaceuticals502 enrolled140 locationsNCT05646381
Recruiting

Clinical and CPET Parameters That Predict Improvement in Functional Capacity After TAVI

Aortic Stenosis Disease
Hospital Clinic of Barcelona161 enrolled1 locationNCT06833762
Recruiting

Derivation and Validation of the Aortic Valve Echocardiographic Calcium Score to Confirm Severe Aortic Stenosis: the Echo-AVCS Study

Calcific Aortic StenosisChronic Coronary SyndromeAortic Stenosis+1 more
Azienda Ospedaliera "Sant'Andrea"250 enrolled5 locationsNCT07620925
Recruiting

Aortic Stenosis - Prognosis, Risk and Outcomes

Aortic Stenosis Disease
Vastra Gotaland Region300 enrolled2 locationsNCT06863883
Recruiting

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Aortic Stenosis
Medtronic Cardiovascular225 enrolled71 locationsNCT06777368
Recruiting
Not Applicable

TRanscatheter Aortic-Valve Implantation Without On-site Cardiac Surgery

Aortic Stenosis
University Hospital of Ferrara1,612 enrolled3 locationsNCT07604402
Recruiting

Identifying Biological Markers of Cardiovascular Events in Patients With Aortic Stenosis or TAVI

Aortic Stenosis
Hospices Civils de Lyon125 enrolled2 locationsNCT06713889
Recruiting

Navitor Japan Study

Severe aortic stenosis
Abbott Medical Devices100 enrolled3 locationsNCT07193888
Recruiting

A Registry to Assess the Efficacy and Safety of Transcatheter Treatment for Aortic Valve Disease at the IRCCS Policlinico San Matteo Foundation in Pavia (Italy).

Severe aortic stenosis
Fondazione IRCCS Policlinico San Matteo di Pavia500 enrolled1 locationNCT07596394
Recruiting

Multicenter Study for the Validation of Willem AI: Aortic StenoSis Early Diagnosis With AI-electrocardiogram Study

Aortic Stenosis
Idoven 1903 S.L.5,000 enrolled2 locationsNCT07479992
Recruiting
Not Applicable

Surgical vs Transcatheter Aortic Valve Replacement in YOUNG Patients

Symptomatic Severe Aortic Stenosis
Ceric Sàrl1,180 enrolled49 locationsNCT06861361
Recruiting
Not Applicable

Structured Shared Decision Making for Patients Undergoing SAVR or TAVR

Aortic Valve StenosisSymptomatic Aortic Stenosis
Insel Gruppe AG, University Hospital Bern140 enrolled1 locationNCT05711186
Recruiting
Not Applicable

Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis

Aortic Stenosis
Dermed Diagnostics, Inc.6 enrolled1 locationNCT07230964
Recruiting

Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank

Williams SyndromeCardiovascular DiseaseSupravalvular Aortic Stenosis
National Heart, Lung, and Blood Institute (NHLBI)1,099 enrolled3 locationsNCT02706639