Aortic Stenosis Clinical Trials

63 recruiting

Aortic Stenosis Trials at a Glance

83 actively recruiting trials for aortic stenosis are listed on ClinicalTrialsFinder across 6 cities in 40 countries. The largest study group is Not Applicable with 34 trials, with the heaviest enrollment activity in Beijing, Boston, and Minneapolis. Lead sponsors running aortic stenosis studies include Second Affiliated Hospital, School of Medicine, Zhejiang University, Insel Gruppe AG, University Hospital Bern, and China National Center for Cardiovascular Diseases.

Browse aortic stenosis trials by phase

Treatments under study

About Aortic Stenosis Clinical Trials

Looking for clinical trials for Aortic Stenosis? There are currently 63 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Aortic Stenosis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Aortic Stenosis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 83 trials

Recruiting

Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank

Williams SyndromeCardiovascular DiseaseSupravalvular Aortic Stenosis
National Heart, Lung, and Blood Institute (NHLBI)1,099 enrolled3 locationsNCT02706639
Recruiting
Not Applicable

Comparison of Evolut FX Versus Sapien 3 Ultra Resilia.

Aortic Stenosis
Christian Juhl Terkelsen1,346 enrolled1 locationNCT06470022
Recruiting
Not Applicable

Transcatheter AortiC Valve Implantation in aorTic stenosIs CardiogenIc Shock

Cardiogenic ShockAortic Stenosis
Rigshospitalet, Denmark30 enrolled1 locationNCT06638268
Recruiting

DELINEATE-Prospective

Valvular Heart DiseaseValve Disease, AorticAortic Stenosis+2 more
Columbia University50 enrolled1 locationNCT07197736
Recruiting
Phase 2

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

Aortic Stenosis
Novartis Pharmaceuticals502 enrolled139 locationsNCT05646381
Recruiting

PERFECT - Portuguese Evolut Registry Studying the Outcomes of Medtronic Evolut™ FX+ TAVI System by Evaluating an Optimal Care Pathway for TAVI

Severe Symptomatic Aortic Stenosis (Defined as New York Heart Association (NYHA) Class ≥ II)
Portuguese Association of Interventional Cardiology500 enrolled12 locationsNCT07343674
Recruiting
Not Applicable

STAR Trial (Siegel Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis)

Aortic StenosisSymptomatic Severe Native Aortic Stenosis
MiRus1,025 enrolled1 locationNCT07278310
Recruiting

Transcatheter Aortic Valve Replacement in Severe Low Flow, Low Gradient Aortic Stenosis

Low Flow, Low Gradient Aortic Stenosis
University of Salerno1,350 enrolled1 locationNCT06589063
Recruiting

AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction

Diastolic DysfunctionAortic Stenosis
Mayo Clinic2,000 enrolled1 locationNCT06580158
Recruiting
Not Applicable

Transaxillary TAVR With Solely Echocardiography Guidance

Aortic Stenosis
Chinese Academy of Medical Sciences, Fuwai Hospital20 enrolled1 locationNCT07035847
Recruiting

Study of the Progression of Chronic Cardiovascular Conditions

Heart FailureHypertensionDilated Cardiomyopathy+9 more
Prolaio5,000 enrolled1 locationNCT07420907
Recruiting

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Aortic Stenosis
Medtronic Cardiovascular225 enrolled70 locationsNCT06777368
Recruiting
Not Applicable

Optimized Expansion of the Implanted Transcatheter Aortic Valve

Valvular Heart DiseaseAortic Stenosis Disease
Ole De Backer620 enrolled10 locationsNCT07042529
Recruiting

Comparative Imaging Assessment of Valvular Heart Disease

Valve Heart DiseaseAortic Stenosis
The Cleveland Clinic200 enrolled1 locationNCT04126018
Recruiting

International Multicenter Study of the Navitor/Navitor Vision Transcatheter Aortic Valve Platform

Severe Native Aortic Stenosis
IRCCS Policlinico S. Donato1,000 enrolled1 locationNCT07359898
Recruiting

Noninvasive Real-Time Arterial Waveform Monitoring for Cardiovascular Disease Assessment

Healthy SubjectsAortic Stenosis DiseaseAortic Regurgitation Disease
Anhui Provincial Cancer Hospital15 enrolled1 locationNCT07350629
Recruiting

Fibrosis in Chronic and Delayed Myocardial Infarction

Carcinoid SyndromeAortic StenosisChemotherapy Induced Systolic Dysfunction
University of Edinburgh180 enrolled1 locationNCT05756608
Recruiting
Not Applicable

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

Aortic Valve StenosisAortic Stenosis, Calcific
Edwards Lifesciences2,250 enrolled80 locationsNCT04889872
Recruiting
Not Applicable

Surgical vs Transcatheter Aortic Valve Replacement in Young Patients

Symptomatic Severe Aortic Stenosis
Ceric Sàrl1,180 enrolled7 locationsNCT06861361
Recruiting

Identifying Biological Markers of Cardiovascular Events in Patients With Aortic Stenosis or TAVI

Aortic Stenosis
Hospices Civils de Lyon125 enrolled2 locationsNCT06713889