RecruitingNCT02919280

Dallas 2K: A Natural History Study of Depression

Sponsor

University of Texas Southwestern Medical Center

Enrollment

2,500 participants

Start Date

Jun 14, 2016

Study Type

OBSERVATIONAL

Conditions

Depression Depression Bipolar

Summary

The primary objective of this initiative is to implement a prospective study that will allow us to identify and validate biosignatures of response to treatments for depression and depression outcome (using an integrated array of participant specific data: socio-demographic, lifestyle, clinical and behavioral assessments, fluid-based biomarkers, genomics, neuroimaging, EEG, and cell-based assays) in a longitudinal cohort of subjects with elevated symptoms of a depressive disorder. Symptom remission across various treatment options will be assessed using questionnaires for symptom changes, antidepressant treatment tolerability and overall quality of life. Other outcomes generated from this study will include rate of change in quantitative measures of brain function, of depression relevant brain regions correlated with systems-levels behavior and other functional neuro-circuitry MRI measures. Rate of change of specified biochemical biomarkers will also be assessed. Integration of these measures will provide an unmatched understanding into the mechanisms of depression and hold tremendous promise for better disease treatment and associated outcomes.

Eligibility

Min Age: 10 Years

Plain Language Summary

Simplified for easier understanding

This long-term study follows a large group of people with depression or mood disorders over many years (the "Dallas 2K" study) to understand the causes, course, and outcomes of depression, including how biology, life experiences, and environment contribute to the illness. **You may be eligible if...** - You are 10 years of age or older - You have been diagnosed with a mood disorder (such as depression or bipolar disorder) based on a structured clinical interview, either currently or at some point in your lifetime - You are able to speak, read, and understand English (or Spanish for parents/guardians of minors) **You may NOT be eligible if...** - You have never been diagnosed with a mood disorder - You are younger than 10 years old This study is observational — researchers follow your health over time to build a richer understanding of depression, which could lead to better treatments and prevention strategies. Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERObservational Study

The Dallas 2K is a 10-year natural history, longitudinal, prospective study of a cohort of 2,500 participants. There is no medication or non-medication treatment or intervention provided by this study.