The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms
An EEG Study to Investigate the Effect of High-dose Vitamin B6 Supplementation on Neural Activity in Relation to Depression and Anxiety Symptoms.
University of Reading
44 participants
Feb 1, 2026
INTERVENTIONAL
Conditions
Summary
This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.
Eligibility
Inclusion Criteria3
- Over 18 years of age and under 41
- Mild to moderate anxiety and/or depression
- Normal or corrected to normal vision
Exclusion Criteria7
- not taking daily dietary supplement containing \>2 mg Vitamin B6
- not taking medication that is a GABA agaonist (our team will check this with you)
- not be pregnant
- no medical history of epilepsy
- no medical history of peripheral neuropathy
- not taking the antibiotic Seromycin (prescribed for tuberclosis or urinary tract infection)
- no history of brain injury or recent concussion
Interventions
100mg PLP in the form of a tablet, taken once a day for 1 week
Placebo supplement in the form of a capsule.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07469462