RecruitingNot ApplicableNCT07469462

The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

An EEG Study to Investigate the Effect of High-dose Vitamin B6 Supplementation on Neural Activity in Relation to Depression and Anxiety Symptoms.


Sponsor

University of Reading

Enrollment

44 participants

Start Date

May 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.


Eligibility

Min Age: 18 YearsMax Age: 41 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether taking a high dose of Vitamin B6 supplements can help reduce symptoms of depression and anxiety. Vitamin B6 plays a role in the brain's calming chemical system (GABA), and researchers want to know if boosting it helps improve mood. **You may be eligible if...** - You are between 18 and 40 years old - You have mild to moderate anxiety and/or depression - You have normal vision or corrected-to-normal vision **You may NOT be eligible if...** - You are already taking a daily supplement containing more than 2 mg of Vitamin B6 - You take a medication that works on the GABA system in the brain (the study team will check this with you) - You are pregnant - You have a history of epilepsy - You have a history of peripheral neuropathy (nerve damage causing tingling or weakness in the hands and feet) - You are taking the antibiotic Seromycin (used for tuberculosis or urinary tract infections) - You have a history of brain injury or a recent concussion Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPyridoxal-5'-Phosphate supplement

100mg PLP in the form of a tablet, taken once a day for 1 week

DRUGPlacebo Supplementation

Placebo supplement in the form of a capsule.


Locations(1)

Harry Pitt Building

Reading, England, United Kingdom

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NCT07469462


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