RecruitingNCT02954419

IgA Nephropathy Biomarkers Evaluation Study (INTEREST)

Sponsor

Sun Yat-sen University

Enrollment

2,000 participants

Start Date

Nov 1, 2016

Study Type

OBSERVATIONAL

Conditions

IgA Nephropathy Glomerular Diseases

Summary

This prospective cohort study is designed to examine the association between blood and urine biomarkers (including genetic variants) and long-term kidney disease progression among 2000 Chinese IgA nephropathy patients with relatively normal kidney function (eGFR≥60 ml/min/1.73 m2).

Eligibility

Min Age: 14 Years

Inclusion Criteria6

Male or female individuals aged 14 years or older
Patients with biopsy-proven primary IgA nephropathy
A renal biopsy available for reviewing must include 10 or more glomeruli.
The first renal biopsy was performed within 3 years.
eGFR ≥ 60 ml/min/1.73 m2 (MDRD formula);
Individuals or their legal representative who are able to understand and have voluntarily signed the informed consent form (ICF).

Exclusion Criteria2

Relatives were diagnosed with biopsy-proven primary IgA nephropathy;
Individuals had secondary IgA nephropathy due to diseases such as diabetes, chronic liver disease and systemic lupus erythematosus.

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