RecruitingPhase 1NCT07054684

Study of BHV-1400 in IgA Nephropathy

An Open-Label Biomarker Study of BHV-1400 in IgA Nephropathy


Sponsor

Biohaven Therapeutics Ltd.

Enrollment

20 participants

Start Date

Jul 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to determine if BHV-1400 is a safe and tolerable treatment in participants with IgA Nephropathy (IgAN).


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This trial tests a new drug called BHV-1400 in people with IgA nephropathy — a kidney disease where a protein called IgA builds up in the kidneys and causes inflammation and progressive kidney damage. BHV-1400 is designed to reduce the IgA deposits and slow down kidney damage. **You may be eligible if...** - You have been diagnosed with IgA nephropathy confirmed by kidney biopsy - You are experiencing signs of progressive kidney damage (such as protein in the urine) - You meet the health criteria to take part in the study **You may NOT be eligible if...** - Your IgA nephropathy is secondary (caused by another condition like liver disease or inflammatory bowel disease) - Your kidney disease is caused by something other than IgA nephropathy - You have severely impaired kidney function or are on dialysis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBHV-1400

BHV-1400 is delivered subcutaneously (SC)


Locations(12)

Site-001

Farmington, Connecticut, United States

Site-003

Miami Lakes, Florida, United States

Site-011

Miami Lakes, Florida, United States

Site-013

Orlando, Florida, United States

Site-005

Pembroke Pines, Florida, United States

Site-008

Lawrenceville, Georgia, United States

Site-009

Hinsdale, Illinois, United States

Site-012

Indianapolis, Indiana, United States

Site-006

Chesterfield, Missouri, United States

Site-002

Dakota Dunes, South Dakota, United States

Site-004

Houston, Texas, United States

Site-007

Leicester, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT07054684


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