RecruitingNot ApplicableNCT03017573

Prospective Biobanking Study in Cancer Patients Aiming at Better Understand the Link Between the Molecular Alterations of the Tumor Itself, Its Microenvironment and Immune Response (SCANDARE)

Sponsor

Institut Curie

Enrollment

1,050 participants

Start Date

Jan 6, 2017

Study Type

INTERVENTIONAL

Conditions

Triple-Negative Breast Cancer Ovarian Cancer Cervical Cancer Sarcoma Head and Neck Cancer Vulva Cancer

Summary

SCANDARE is a prospective biobanking study on tumor (+/- nodes), plasma and blood samples at different time points in ovarian, triple negative breast, Head and Neck Cancer, advanced stage treatment-naïve cervical or vulva cancer and sarcoma (breast angiosarcoma and uterine sarcoma) cancers. This study will allowed to identify new molecular and/or immunological biomarkers associated with clinical and biological features of the tumors. All patients will receive standard treatment according to the stage of the diseases and usual procédures.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study collects tumor tissue and blood samples from cancer patients before treatment to better understand how the tumor, its surrounding environment, and the immune system interact — with the goal of improving future cancer treatments. **You may be eligible if...** - You are 18 or older - You have been newly diagnosed (and not yet treated) with one of the following cancers: ovarian, triple-negative breast, head and neck, vulvar, cervical, or certain sarcomas - You are scheduled for surgery or pre-surgery chemotherapy - You have signed a consent form **You may NOT be eligible if...** - You are under 18 years old - You have conditions (psychological, family, social, or geographic) that would make it hard to follow the study schedule - You are legally under guardianship or do not have access to a national social security system Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURETumor biopsies / Tumor surgery

Tumoral tissues samples must be collected at different times points : * at the time of surgery * before first cycle of adjuvant treatment (if possible) * at progression (if possible) OR * before neoadjuvant therapy * at the time of surgery * before first cycle of adjuvant treatment (if possible) * at progression (if possible)

PROCEDUREBlood withdrawal

Blood samples must be collected at different times points : * at the time of surgery or before the beginning of chemoradiotherapy * after surgery or after chemoradiotherapy * 6 months after surgery if non recurrence * before first cycle of adjuvant treatment or before radiotherapy * before second cycle of adjuvant treatment or after radiotherapy * at progression OR * before neoadjuvant therapy * during neoadjuvant therapy (post cycle 1) * at the time of surgery * 6 months after surgery if non recurrence * before first cycle of adjuvant treatment or before radiotherapy * before second cycle of adjuvant treatment or after radiotherapy * at progression