Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes

This study uses advanced genetic testing (next-generation sequencing) to look for inherited gene changes in patients with acute myeloid leukemia (AML) or a pre-leukemia condition (myelodysplastic syndrome, or MDS) who have family members with similar blood disorders — to understand whether the condition runs in families. **You may be eligible if...** - You have been diagnosed with AML or MDS - You have a close relative (parent, sibling, child, grandparent, aunt/uncle) who also has AML, MDS, or another blood cancer or immune system cancer - OR you have symptoms suggesting a hereditary form of AML/MDS, such as: a history of low platelets or unusual bleeding, abnormal nails or skin, immune deficiency, or swollen lymph nodes **You may NOT be eligible if...** - Your diagnosis is something other than AML or MDS - You have AML or MDS without any family history of blood or immune cancers and without features of a hereditary predisposition syndrome - You are unable to sign an informed consent form Talk to your doctor to see if this trial is right for you.